PMID- 7739993
OWN - NLM
STAT- MEDLINE
DCOM- 19950602
LR  - 20190904
IS  - 0197-3851 (Print)
IS  - 0197-3851 (Linking)
VI  - 15
IP  - 1
DP  - 1995 Jan
TI  - Identification of abnormal chromosomal complement in formalin-fixed, 
      paraffin-embedded placental tissue.
PG  - 21-6
AB  - The objective of this project was to assess the efficacy of fluorescence in situ 
      hybridization (FISH) with chromosome-specific DNA probes to identify chromosome 
      number in formalin-fixed, paraffin-embedded placental specimens. Using this 
      approach, 75 per cent of the karyotypes in 20 formalin-fixed placental samples 
      (comprising aneuploids, triploids, and normals) were correctly identified. As 
      this technology improves, the ability to obtain information regarding chromosomal 
      abnormalities in formalin-fixed, paraffin-embedded placental tissue should 
      improve as well. This technology can potentially provide important cytogenetic 
      information even when fresh tissue is not available for standard karyotypic 
      analysis.
FAU - Cowles, T A
AU  - Cowles TA
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, University of 
      Texas, Houston, Health Science Center, USA.
FAU - Elder, F F
AU  - Elder FF
FAU - Taylor, S
AU  - Taylor S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
RN  - 0 (DNA Probes)
RN  - 0 (Fixatives)
RN  - 1HG84L3525 (Formaldehyde)
RN  - 8002-74-2 (Paraffin)
SB  - IM
MH  - *Chromosome Aberrations
MH  - DNA Probes
MH  - Female
MH  - Fixatives
MH  - Formaldehyde
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Paraffin
MH  - Placenta/*ultrastructure
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - *Tissue Embedding
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1002/pd.1970150106 [doi]
PST - ppublish
SO  - Prenat Diagn. 1995 Jan;15(1):21-6. doi: 10.1002/pd.1970150106.