PMID- 7740051
OWN - NLM
STAT- MEDLINE
DCOM- 19950602
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 50
IP  - 2
DP  - 1995 Feb
TI  - IL-1 beta and TNF alpha modulate delta 9-tetrahydrocannabinol-induced catalepsy 
      in mice.
PG  - 141-6
AB  - The role of the proinflammatory cytokines interleukin-1 alpha (IL-1 alpha), 
      interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis 
      factor-alpha (TNF alpha) in THC-induced catalepsy in mice was examined. 
      Recombinant IL-1 beta (400 ng/mouse, IV) and TNF alpha (500 ng/mouse, IV) were 
      effective in potentiating the cataleptic effect of low-dose THC (10 
      micrograms/mouse, IV). Recombinant IL-1 alpha and IL-6 did not potentiate 
      catalepsy at any dose tested. Anti-IL-1 beta and anti-TNF alpha antibodies were 
      effective in attenuating high-dose (75 micrograms/mouse) THC-induced catalepsy. 
      Antibodies to IL-1 alpha and IL-6 had no effect on catalepsy. Early onset 
      catalepsy (10 min postinjection) was potentiated by exogenous recombinant IL-1 
      beta and TNF alpha but only later catalepsy (2 h postinjection) was attenuated by 
      antibodies to endogenous IL-1 beta or TNF alpha. This divergence of the cytokine 
      effect suggests that these substances regulate, by different mechanisms, the 
      early and late THC-induced cataleptic response.
FAU - Gibertini, M
AU  - Gibertini M
AD  - Department of Medical Microbiology and Immunology, University of South Florida, 
      Tampa 33612, USA.
FAU - Newton, C
AU  - Newton C
FAU - Friedman, H
AU  - Friedman H
FAU - Klein, T W
AU  - Klein TW
LA  - eng
GR  - DA 03646/DA/NIDA NIH HHS/United States
GR  - DA 07245/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Antibodies)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7J8897W37S (Dronabinol)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology
MH  - Catalepsy/chemically induced/*prevention & control
MH  - Dose-Response Relationship, Drug
MH  - *Dronabinol
MH  - Female
MH  - Interleukin-1/*pharmacology
MH  - Interleukin-6/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Recombinant Proteins/pharmacology
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 0091-3057(94)00270-S [pii]
AID - 10.1016/0091-3057(94)00270-s [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1995 Feb;50(2):141-6. doi: 10.1016/0091-3057(94)00270-s.