PMID- 7743215
OWN - NLM
STAT- MEDLINE
DCOM- 19950615
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 671
IP  - 2
DP  - 1995 Feb 13
TI  - Spatio-temporal summation of synaptic activity in visual cortical pyramidal cells 
      in vitro.
PG  - 275-81
AB  - We investigated the spatio-temporal summation of excitatory postsynaptic 
      potentials (EPSPs) in supragranular pyramidal cells of the rat extrastriate 
      visual cortex. EPSPs were evoked orthodromically from different locations within 
      the white matter (WM) via an 8-fold multi-electrode array. Stimuli were applied 
      either sequentially from electrodes 1 to 8 or vice versa at defined interstimulus 
      intervals (ISIs) or separately from each electrode. Maximum EPSP amplitudes were 
      evoked from the WM just below the intracellularly recorded neuron. Even 800 
      microns lateral to this location, small EPSPs could be elicited. A sequential 
      stimulation resulted in a large compound EPSP. In 79% (n = 34) of the cells 
      tested, the compound response was non-directional and could be predicted from 
      responses evoked by single stimulation electrodes. However, 21% (n = 9) of the 
      neurons showed a non-linear spatial summation and a clear preference for the 
      direction of the stimulation sequence. ISI-tuning curves revealed either a 
      sharply tuned, a bandpass, a highpass or a lowpass characteristic for the 
      non-directional as well as directional cells. This feature, together with the 
      clear directional responses observed in some neurons, may be a correlate of the 
      response preference to moving stimuli of cortical cells found in vivo.
FAU - Lohmann, H
AU  - Lohmann H
AD  - Department of General Zoology and Neurobiology, Ruhr-University Bochum, Germany.
FAU - Algur, Y
AU  - Algur Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - G6D6147J22 (biocytin)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Animals
MH  - Electric Stimulation
MH  - Electrodes
MH  - Evoked Potentials/drug effects/physiology
MH  - Female
MH  - Lysine/analogs & derivatives/pharmacology
MH  - Male
MH  - Membrane Potentials/drug effects/physiology
MH  - Pyramidal Cells/drug effects/*physiology
MH  - Rats
MH  - Synapses/drug effects/*physiology
MH  - Time Factors
MH  - Visual Cortex/anatomy & histology/cytology/*physiology
EDAT- 1995/02/13 00:00
MHDA- 1995/02/13 00:01
CRDT- 1995/02/13 00:00
PHST- 1995/02/13 00:00 [pubmed]
PHST- 1995/02/13 00:01 [medline]
PHST- 1995/02/13 00:00 [entrez]
AID - 0006-8993(94)01346-J [pii]
AID - 10.1016/0006-8993(94)01346-j [doi]
PST - ppublish
SO  - Brain Res. 1995 Feb 13;671(2):275-81. doi: 10.1016/0006-8993(94)01346-j.