PMID- 7745969
OWN - NLM
STAT- MEDLINE
DCOM- 19950613
LR  - 20190821
IS  - 0022-4790 (Print)
IS  - 0022-4790 (Linking)
VI  - 59
IP  - 1
DP  - 1995 May
TI  - Wilms' tumor: the Northern Israel Oncology Institute experience.
PG  - 10-3
AB  - Between 1971 and 1992, 42 children (median age = 2 years) with histologically 
      proven Wilms' tumor were evaluated at the Northern Israel Oncology Institute. 
      Most patients were staged according to National Wilms' Tumor Study (NWTS) 
      criteria by which 18 were clinical stage I-II and 24 were III-IV. Combined 
      therapy (surgery, chemotherapy, and radiotherapy) was given with a change to 
      lower dose radiotherapy (< 2,000 cG) after 1981. The pre-1981 group (13 patients) 
      suffered six relapses, most of which were pulmonary, whereas the 1981-1992 group 
      (29 patients) had three relapses. The actuarial 5-year survival rate using 
      Kaplan-Meier tables was 79% for the entire group but 100% for the 1981-1992 group 
      and 38% for the 1971-1980 group. One case of immediate hepatic toxicity and one 
      sudden death, unknown cause, of a patient in remission occurred in the group. 
      Late deleterious effects were seen in five other patients; four had scoliosis and 
      one developed osteoid osteoma of a rib. Despite these encouraging results, the 
      necessity of ongoing monitoring for further long-term toxicities is apparent.
FAU - Ben Arush, M W
AU  - Ben Arush MW
AD  - Pediatric Oncology Unit, Northern Isreal Oncology Institute, Rambam Medical 
      Center, Haifa, Israel.
FAU - Nahum, M P
AU  - Nahum MP
FAU - Maor, J A
AU  - Maor JA
FAU - Dale, J
AU  - Dale J
FAU - Kuten, A
AU  - Kuten A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Surg Oncol
JT  - Journal of surgical oncology
JID - 0222643
SB  - IM
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Israel/epidemiology
MH  - Kidney Neoplasms/*epidemiology/mortality/pathology/therapy
MH  - Lymphatic Metastasis
MH  - Male
MH  - Neoplasm Staging
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Wilms Tumor/*epidemiology/mortality/pathology/therapy
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1002/jso.2930590104 [doi]
PST - ppublish
SO  - J Surg Oncol. 1995 May;59(1):10-3. doi: 10.1002/jso.2930590104.