PMID- 7747528
OWN - NLM
STAT- MEDLINE
DCOM- 19950609
LR  - 20190201
IS  - 0001-5555 (Print)
IS  - 0001-5555 (Linking)
VI  - 75
IP  - 1
DP  - 1995 Jan
TI  - Identical HLA class II alleles predispose to drug-triggered and idiopathic 
      pemphigus vulgaris.
PG  - 12-4
AB  - In pemphigus vulgaris, a dermatological autoimmune disease, specific human 
      leukocyte antigen (HLA) class II alleles, DR4 (DRB1*0402) and DRw14 (DRB1*1401, 
      in linkage disequilibrium with DQB1*0503), are thought to be susceptibility genes 
      involved in the onset of the disease. We studied the HLA class II alleles (DQA1, 
      DQB1, DRB1 and DPB1) of 6 patients with pemphigus, in whom the disease was 
      "triggered" by drugs containing sulphydryl or another sulphur-containing group. 
      All patients carried the DRB1*0402 susceptibility allele, and one patient also 
      carried the second susceptibility allele, namely DQB1*0503 (in linkage with 
      DRB1*1401). Bacterial, viral or environmental agents are suspected to trigger the 
      onset of autoimmune diseases. Our study demonstrated the presence in patients 
      with drug-triggered pemphigus vulgaris of the same HLA alleles thought to 
      predispose to idiopathic pemphigus vulgaris. This finding strengthens the notion 
      that these HLA alleles may be true disease susceptibility genes.
FAU - Matzner, Y
AU  - Matzner Y
AD  - Hematology Unit, Hadassah University Hospitals, Mount Scopus, Israel.
FAU - Erlich, H A
AU  - Erlich HA
FAU - Brautbar, C
AU  - Brautbar C
FAU - Sanilevitch, A
AU  - Sanilevitch A
FAU - Landau, M
AU  - Landau M
FAU - Brenner, S
AU  - Brenner S
FAU - Friedmann, A
AU  - Friedmann A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR14)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:02 antigen)
RN  - 0 (Sulfhydryl Compounds)
RN  - 70FD1KFU70 (Sulfur)
SB  - IM
GS  - DQB1*0503
GS  - DRB1*0402
GS  - DRB1*1401
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Autoimmune Diseases/*genetics
MH  - Disease Susceptibility
MH  - Female
MH  - Genetic Linkage/genetics
MH  - HLA Antigens/*genetics
MH  - HLA-DP Antigens/genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DR Serological Subtypes
MH  - HLA-DR4 Antigen/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pemphigus/chemically induced/genetics/*immunology
MH  - Sulfhydryl Compounds/adverse effects
MH  - Sulfur/adverse effects
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.2340/00015555751214 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 1995 Jan;75(1):12-4. doi: 10.2340/00015555751214.