PMID- 7747600
OWN - NLM
STAT- MEDLINE
DCOM- 19950614
LR  - 20200106
IS  - 0736-5748 (Print)
IS  - 0736-5748 (Linking)
VI  - 12
IP  - 8
DP  - 1994 Dec
TI  - Intracerebroventricular injection of streptozotocin induces discrete local 
      changes in cerebral glucose utilization in rats.
PG  - 737-43
AB  - The purpose of the present study was to investigate whether or not cerebral 
      glucose utilization is changed locally after damage of the neuronal insulin 
      receptor by means of intracerebroventricular (icv) streptozotocin (STZ) 
      administered in a subdiabetogenic dosage (1.5 mg/kg bw.). STZ was administered at 
      the start of the study, and 2 and 21 days later bilaterally into the cerebral 
      ventricles in rats of a mean age of 18 months. The local distribution of cerebral 
      glucose utilization was analyzed in conscious rats on the 42nd day after the 
      first STZ injection using the quantitative (14C)-2-deoxyglucose method. Of the 35 
      brain structures investigated from autoradiograms of brain sections, 17 showed a 
      reduction in glucose utilization. Decreases in glucose utilization were observed 
      in the frontal, parietal, sensory motor, auditory and entorhinal cortex and in 
      all hippocampal subfields. In contrast, glucose utilization was increased in two 
      white matter structures. The decrease in cerebral glucose utilization observed in 
      cortical and hippocampal areas in the present study may correspond to changes in 
      morphobiological parameters which have been found in patients with Alzheimer's 
      disease. The present data are in accordance with the hypothesis that an 
      impairment in the control of neuronal glucose metabolism at the insulin receptor 
      site may exist in sporadic dementia of Alzheimer type (DAT), and can be studied 
      by the icv STZ animal model.
FAU - Duelli, R
AU  - Duelli R
AD  - Department of Physiology, University of Heidelberg, Germany.
FAU - Schrock, H
AU  - Schrock H
FAU - Kuschinsky, W
AU  - Kuschinsky W
FAU - Hoyer, S
AU  - Hoyer S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 5W494URQ81 (Streptozocin)
RN  - EC 2.7.10.1 (Receptor, Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Disease Models, Animal
MH  - Frontal Lobe/metabolism
MH  - Glucose/*metabolism
MH  - Hemodynamics
MH  - Injections, Spinal
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Insulin/metabolism
MH  - Streptozocin/*pharmacology
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 0736-5748(94)90053-1 [pii]
AID - 10.1016/0736-5748(94)90053-1 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 1994 Dec;12(8):737-43. doi: 10.1016/0736-5748(94)90053-1.