PMID- 7749099
OWN - NLM
STAT- MEDLINE
DCOM- 19950620
LR  - 20211203
IS  - 0340-4684 (Print)
IS  - 0340-4684 (Linking)
VI  - 20
IP  - 2-3
DP  - 1994
TI  - Umbilical cord blood transplantation: overview of the clinical experience.
PG  - 227-33; discussion 233-4
AB  - In an attempt to reduce the morbidity and mortality associated with allogeneic 
      bone marrow transplantation, clinical investigators in Asia, Australia, Europe, 
      and North America have evaluated umbilical cord and placental blood as an 
      alternate source of hematopoietic stem and progenitor cells for transplantation. 
      To date, umbilical cord blood has been used to reconstitute hematopoiesis in 34 
      patients with a variety of malignant and nonmalignant diseases treated with 
      myeloablative therapy. Although the median number of nucleated cells infused was 
      only 4.0 x 10(7)/kg of the recipient's body weight (range, 0.1-33.0 x 10(7)), the 
      median time to hematopoietic recovery was 25.0 days for neutrophils (i.e., 
      absolute neutrophil count > 500/microL, range, 12-46) and 43.5 days for platelets 
      (i.e., absolute platelet count > 50,000/microL, range: 15-105+). Except in three 
      patients who failed to demonstrate any evidence of hematopoietic recovery and one 
      patient who had prompt autologous recovery, engraftment of donor cells was 
      documented in all patients, including recipients of HLA-mismatched grafts. Of 23 
      evaluable patients with HLA-identical or HLA-1 antigen-mismatched donors, none 
      had grade 2-4 acute graft vs. host disease (GVHD). In summary, these data suggest 
      that umbilical cord blood is an acceptable source of transplantable hematopoietic 
      stem cells, at least in recipients < 40 kg and that the risk of acute GVHD is 
      low.
FAU - Wagner, J E
AU  - Wagner JE
AD  - Bone Marrow Transplantation Program, University of Minnesota School of Medicine, 
      Minneapolis, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Blood Cells
JT  - Blood cells
JID - 7513567
SB  - IM
CIN - Blood Cells. 1994;20(2-3):242-4. PMID: 7749100
MH  - Adolescent
MH  - Blood Cell Count
MH  - Blood Group Incompatibility
MH  - Bone Marrow Diseases/chemically induced/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Fetal Blood/*cytology
MH  - Graft Survival
MH  - Graft vs Host Disease/epidemiology/prevention & control
MH  - Hematopoiesis
MH  - *Hematopoietic Stem Cell Transplantation/methods/statistics & numerical data
MH  - Histocompatibility
MH  - Humans
MH  - Immunosuppression Therapy
MH  - Infant
MH  - Registries
MH  - Retrospective Studies
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Blood Cells. 1994;20(2-3):227-33; discussion 233-4.