PMID- 7749107
OWN - NLM
STAT- MEDLINE
DCOM- 19950620
LR  - 20191210
IS  - 0340-4684 (Print)
IS  - 0340-4684 (Linking)
VI  - 20
IP  - 2-3
DP  - 1994
TI  - The use of umbilical cord blood in mismatched related and unrelated hemopoietic 
      stem cell transplantation.
PG  - 275-83; discussion 284
AB  - Over the past 6 years, umbilical cord blood has emerged as an efficacious 
      alternative source of hematopoietic stem cells in related bone marrow 
      transplantation. These encouraging results led us to extend this technology to 
      the mismatched related and unrelated settings in three high-risk leukemic 
      children lacking a matched-related donor for transplantation. Two of the three 
      children also lacked identifiable donors through the National Marrow Donor 
      Program, while the third was in relapse and did not have time to wait for 
      completion of a search. The first child was transplanted with haploidentical 
      umbilical cord blood-derived mononuclear cells from his sister, while the 
      remaining two children were transplanted with partially mismatched, unseparated, 
      unrelated umbilical cord blood banked through the Placental Blood Project at the 
      New York Blood Center. All three children demonstrated trilineage engraftment 
      with donor cells within 6 weeks of transplantation. The patient transplanted with 
      haploidentical marrow developed grade 2 graft vs. host disease (GVHD), which was 
      controlled with steroid and anti-thymocyte globulin (ATG) therapy. One of the two 
      patients grafted with unrelated umbilical cord blood developed mild grade 1 GVHD 
      of the skin, which rapidly cleared with steroid therapy. One patient remains 
      alive, in good health and disease-free 12 months from transplantation.
FAU - Kurtzberg, J
AU  - Kurtzberg J
AD  - Pediatric Bone Marrow Transplant Program, Duke University Medical Center, Durham, 
      North Carolina 27710, USA.
FAU - Graham, M
AU  - Graham M
FAU - Casey, J
AU  - Casey J
FAU - Olson, J
AU  - Olson J
FAU - Stevens, C E
AU  - Stevens CE
FAU - Rubinstein, P
AU  - Rubinstein P
LA  - eng
GR  - 1R18HL48031-01/HL/NHLBI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood Cells
JT  - Blood cells
JID - 7513567
SB  - IM
MH  - Acute Disease
MH  - Child
MH  - Child, Preschool
MH  - Fatal Outcome
MH  - Female
MH  - Fetal Blood/*cytology/immunology
MH  - Graft Survival
MH  - Graft vs Host Disease/etiology/prevention & control
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Histocompatibility
MH  - Humans
MH  - Infant
MH  - Infections/etiology
MH  - Leukemia, Myeloid/*therapy
MH  - Leukemia-Lymphoma, Adult T-Cell/*therapy
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*therapy
MH  - Pulmonary Edema/etiology
MH  - Remission Induction
MH  - Salvage Therapy
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Blood Cells. 1994;20(2-3):275-83; discussion 284.