PMID- 7749108
OWN - NLM
STAT- MEDLINE
DCOM- 19950620
LR  - 20060424
IS  - 0340-4684 (Print)
IS  - 0340-4684 (Linking)
VI  - 20
IP  - 2-3
DP  - 1994
TI  - Unrelated, HLA-mismatched multiple human umbilical cord blood transfusion in four 
      cases with advanced solid tumors: initial studies.
PG  - 285-92
AB  - Four patients with advanced solid tumors were treated by means of high-dose 
      chemotherapy and HLA-mismatched and unrelated multi-cord blood transfusion. Of 
      these patients, three achieved complete remission and one achieved a partial 
      remission. Little or no graft vs. host disease (GVHD) was observed. Partial donor 
      cell engraftment was suggested by 101 to 320 days for two patients by cytogenetic 
      analysis and hemoglobin F levels in the peripheral blood. Recurrent disease was 
      confirmed clinically on day 210 (4-year-old girl with liposarcoma) and on day 90 
      (11-year-old boy with non-Hodgkin's lymphoma). These results suggest the 
      possibility that HLA-mismatched and unrelated multi-cord blood transfusion may 
      engraft with little or no GVHD and hasten recovery from marrow suppression that 
      is due to chemotherapy. It remains to be determined, however, whether these 
      results document true stem/progenitor cell engraftment or alternatively transient 
      engraftment of more mature cells along with repopulation by autologous cells.
FAU - Shen, B J
AU  - Shen BJ
AD  - Department of Pediatrics, Affiliated Hospital, Shandong Medical University, 
      People's Republic of China.
FAU - Hou, H S
AU  - Hou HS
FAU - Zhang, H Q
AU  - Zhang HQ
FAU - Sui, X W
AU  - Sui XW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Blood Cells
JT  - Blood cells
JID - 7513567
SB  - IM
CIN - Blood Cells. 1994;20(2-3):293-5. PMID: 7749109
MH  - Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use
MH  - Blood Grouping and Crossmatching
MH  - Bone Marrow Diseases/chemically induced/therapy
MH  - Child
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Endodermal Sinus Tumor/drug therapy/therapy
MH  - Female
MH  - Fetal Blood/*cytology
MH  - Graft Survival
MH  - Graft vs Host Disease/etiology
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Histocompatibility
MH  - Humans
MH  - Liposarcoma/drug therapy/therapy
MH  - Lymphoma, Non-Hodgkin/drug therapy/therapy
MH  - Male
MH  - Neoplasms/drug therapy/*therapy
MH  - Neuroblastoma/drug therapy/therapy
MH  - Neurofibroma/pathology
MH  - Pelvic Neoplasms/drug therapy/therapy
MH  - Remission Induction
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Blood Cells. 1994;20(2-3):285-92.