PMID- 7749121
OWN - NLM
STAT- MEDLINE
DCOM- 19950620
LR  - 20061115
IS  - 0340-4684 (Print)
IS  - 0340-4684 (Linking)
VI  - 20
IP  - 2-3
DP  - 1994
TI  - Cord blood transplantation: implications for graft vs. host disease and graft vs. 
      leukemia.
PG  - 560-4; discussion 564-5
AB  - Cord blood (CB) was analyzed for its alloreactive immune potential to evaluate 
      its capacity to mediate graft vs. host disease (GVHD) and graft vs. leukemia 
      (GVL) effects. Cord blood was observed to display minimal innate cytotoxic 
      capacity but was capable of rapidly developing significant nonspecific natural 
      killer cell-like effector mechanisms. Cord blood was unable to generate effective 
      alloantigen-specific cytotoxic T lymphocytes (CTL), which was at least partially 
      due to an altered lymphokine profile. The frequency of alloreactive T cells 
      present in CB (whether assessed as total responding T-cell or CTL precursors) was 
      greatly reduced as compared to adult peripheral blood lymphocytes (PBLs). 
      However, the frequency of nonspecific effector cells was equivalent to PBLs. 
      Significantly, CB T cells seemed to have undergone some type of developmental 
      tolerance to maternal HLA antigens in utero, which could greatly increase the 
      utility of CB in familial transplants. That is, CB T cells were unresponsive to 
      noninherited maternal HLA antigens. Finally, CB demonstrated significant GVL 
      capacity whether measured in vitro or in an animal model in vivo. Thus, the use 
      of CB in most transplant settings should be free of the immunological problems 
      associated with GVHD yet still be an effective mediator of GVL.
FAU - Harris, D T
AU  - Harris DT
AD  - Department of Microbiology and Immunology, University of Arizona, Tucson 85721, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood Cells
JT  - Blood cells
JID - 7513567
RN  - 0 (HLA Antigens)
RN  - 0 (Lymphokines)
SB  - IM
MH  - Cytotoxicity, Immunologic
MH  - Female
MH  - Fetal Blood/*cytology/immunology
MH  - Graft vs Host Disease/*etiology/prevention & control
MH  - HLA Antigens/genetics/immunology
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - Immune Tolerance
MH  - Killer Cells, Natural/immunology/*transplantation
MH  - Leukemia/immunology/*therapy
MH  - Lymphokines/blood
MH  - Pregnancy/immunology
MH  - T-Lymphocyte Subsets/immunology/*transplantation
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Blood Cells. 1994;20(2-3):560-4; discussion 564-5.