PMID- 7749200
OWN - NLM
STAT- MEDLINE
DCOM- 19950620
LR  - 20190606
IS  - 0916-8737 (Print)
IS  - 0916-8737 (Linking)
VI  - 30
IP  - 4
DP  - 1994 Aug
TI  - Comparison of endothelium-dependent and -independent tension oscillation in 
      aortae of stroke-prone spontaneously hypertensive rats and Wistar Kyoto rats.
PG  - 135-45
AB  - Differences in noradrenaline-induced tension oscillations between aortae from 
      stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive control 
      Wistar Kyoto rats (WKY) were studied. Endothelium-intact and -removed ring 
      preparations were made from thoracic aorta of SHRSP and WKY, and isometric 
      contraction was observed. Endothelium-intact preparations from WKY showed tension 
      oscillations in response to high concentration of noradrenaline at significantly 
      higher ratio, while only a few endothelium-removed preparation showed tension 
      oscillations in response to low concentration of the drug. Fifteen out of 41 
      endothelium-removed preparations from SHRSP showed tension oscillations in 
      response to low concentration of noradrenaline but no preparation showed 
      oscillations in response to high concentration of the drug. Seven and 14 out of 
      42 endothelium-intact preparations from SHRSP showed oscillatory response to low 
      and high concentration of the drug, respectively. Acetylcholine-induced 
      relaxation and tension oscillations, both of which being significantly less in 
      the preparation from SHRSP. Both the endothelium-independent tension oscillations 
      and endothelium-dependent tension oscillations were abolished by removal of 
      extracellular Ca or by verapamil. It is suggested that aortic smooth muscle of 
      SHRSP possesses the property which produced tension oscillations, while the 
      tension oscillations of WKY aorta is endothelium-dependent. The opening of 
      voltage-dependent Ca++ channel of smooth muscle cell membrane which generates 
      rhythmic contraction is increased in the aorta of SHRSP, while the release of 
      endothelium-derived factors which induces rhythmic activities of smooth muscle 
      cell is decreased.
FAU - Sunano, S
AU  - Sunano S
AD  - Research Institute of Hypertension, Kinki University, Osaka-Sayama, Japan.
FAU - Sasaki, F
AU  - Sasaki F
FAU - Osugi, S
AU  - Osugi S
FAU - Shimamura, K
AU  - Shimamura K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - J Smooth Muscle Res
JT  - Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi
JID - 9211664
RN  - 0 (Calcium Channels)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/drug effects/physiology
MH  - Calcium Channels/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Endothelium, Vascular/*physiology
MH  - In Vitro Techniques
MH  - *Isometric Contraction/drug effects
MH  - Male
MH  - Muscle, Smooth, Vascular/drug effects/*physiology
MH  - Norepinephrine/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 10.1540/jsmr.30.135 [doi]
PST - ppublish
SO  - J Smooth Muscle Res. 1994 Aug;30(4):135-45. doi: 10.1540/jsmr.30.135.