PMID- 7750054
OWN - NLM
STAT- MEDLINE
DCOM- 19950621
LR  - 20221207
IS  - 0578-1337 (Print)
IS  - 0578-1337 (Linking)
VI  - 55
IP  - 2
DP  - 1995 Feb
TI  - Lupus in Chinese male: a retrospective study of 61 patients.
PG  - 143-50
AB  - BACKGROUND: Systemic lupus erythematosus (SLE) has traditionally been considered 
      a disease of women, and is uncommon in men. In recent years, several large 
      clinical series of male lupus patients have been reported. As no known data are 
      available for lupus in males from Taiwan, a retrospective analysis of data from 
      male lupus patients was done to determine whether these patients differed from 
      other series of male or female SLE patients in the literature. METHODS: Sixty-one 
      male lupus patients, diagnosed and followed in Tri-Service General Hospital, 
      between 1983 and 1993, were studied and their data analyzed, retrospectively. 
      RESULTS: The mean age of diagnosis was 30 +/- 17 (mean +/- SD, range: 13-81) 
      years. The peak age of diagnosis was between 13 and 40 years. The mean duration 
      of follow-up was 36 +/- 36 (range: 2-256) months. The 1-, 5- and 10-year survival 
      rates were 84%, 76% and 75%, respectively. The frequency of clinical 
      manifestations were renal disease, 75%; malar rash, 70%; arthritis, 60%; fever, 
      56%; photosensitivity, 48%; pleuritis, 39%; pericarditis, 31%; alopecia, 31%; 
      mucosal ulcers, 29%; neuropsychiatric disease, 26%; discoid lupus, 21%; 
      vasculitis, 15%; Raynaud's phenomenon, 10%; and lymphadenopathy, 2%. The 
      frequency of abnormal laboratory findings were antinuclear antibodies (ANA), 95%; 
      hypocomplementemia, 77%; antibodies to double-stranded DNA (anti-dsDNA), 57%; 
      leukopenia, 44%; lupus erythematosus (LE) cells, 39%; anti-Ro, 39%; anti-Smith 
      antibodies (anti-Sm), 19%; thrombocytopenia, 18%; rheumatoid factor, 17%; 
      anti-ribonucleoprotein antibody (anti-RNP), 14%; autoimmune hemolytic anemia, 8%; 
      false-positive venereal disease research laboratory test (VDRL), 6% and anti-La, 
      4%. CONCLUSIONS: In a review of the 61 ethnic Chinese male lupus patients, a 
      higher frequency of renal disease, malar rash and photosensitivity, but a lower 
      frequency of arthritis and lymphadenopathy, compared to previous reports of 
      Caucasians. There were no significant immunological differences from other series 
      of male lupus, except a lower frequency of anti-dsDNA. In general, poor prognosis 
      was noted for male lupus patients here.
FAU - Chang, C C
AU  - Chang CC
AD  - Department of Internal Medicine, Taipei Municipal Jen-Ai Hospital, Taiwan, R.O.C.
FAU - Shih, T Y
AU  - Shih TY
FAU - Chu, S J
AU  - Chu SJ
FAU - Kuo, S Y
AU  - Kuo SY
FAU - Chen, C M
AU  - Chen CM
FAU - Hsu, C M
AU  - Hsu CM
FAU - Chang, M L
AU  - Chang ML
FAU - Chang, D M
AU  - Chang DM
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Zhonghua Yi Xue Za Zhi (Taipei)
JT  - Zhonghua yi xue za zhi = Chinese medical journal; Free China ed
JID - 0005327
RN  - 0 (Antibodies, Antinuclear)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Antinuclear/analysis
MH  - Asian People
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lupus Erythematosus, Systemic/diagnosis/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Taiwan
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi (Taipei). 1995 Feb;55(2):143-50.