PMID- 7750500
OWN - NLM
STAT- MEDLINE
DCOM- 19950619
LR  - 20071114
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 136
IP  - 6
DP  - 1995 Jun
TI  - Monocyte chemoattractant protein-1 expression and monocyte recruitment in osseous 
      inflammation in the mouse.
PG  - 2752-9
AB  - In bone, early events in inflammation involve the production and release of 
      primary proinflammatory cytokines, such as interleukin-1 beta. By activation of 
      target cells, these cytokines are thought to induce a second wave of cytokines, 
      including monocyte chemoattractant protein-1 (MCP-1). MCP-1 is a cytokine that 
      stimulates chemotaxis of monocytes. Experiments were undertaken to examine the 
      expression of MCP-1 in bone-associated cells in vivo. To observe in vivo 
      expression of MCP-1, an inflammatory lesion was created in the murine mandible. 
      Immunohistochemistry experiments using specific antibodies to MCP-1 were 
      conducted to identify MCP-1-expressing cells in inflamed and noninflamed bone. We 
      found that osteoblasts were the principal cells expressing MCP-1 in inflamed 
      bone. There was little or no MCP-1 expression in noninflamed bone. 
      Immunohistochemistry experiments were carried out to assess monocyte recruitment 
      during osseous inflammation. The number of MCP-1-positive cells was significantly 
      correlated to the number of monocytes/macrophages present (n = 15; r = 0.69; P < 
      = 0.01). These in vivo results strongly suggest that MCP-1 is an important 
      mediator involved in the recruitment of monocytes/macrophages in inflamed bone.
FAU - Rahimi, P
AU  - Rahimi P
AD  - Department of Oral Biology, Boston University School of Graduate Dentistry, 
      Massachusetts 02118, USA.
FAU - Wang, C Y
AU  - Wang CY
FAU - Stashenko, P
AU  - Stashenko P
FAU - Lee, S K
AU  - Lee SK
FAU - Lorenzo, J A
AU  - Lorenzo JA
FAU - Graves, D T
AU  - Graves DT
LA  - eng
GR  - AR-42362/AR/NIAMS NIH HHS/United States
GR  - DE-07559/DE/NIDCR NIH HHS/United States
GR  - DE-09581/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
SB  - IM
MH  - Animals
MH  - Bone Resorption/metabolism/pathology
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*metabolism
MH  - Chemotaxis
MH  - Immunohistochemistry
MH  - Macrophages/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Monocytes/*pathology
MH  - Osteitis/etiology/*metabolism/*pathology
MH  - Osteoclasts/metabolism/pathology
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 10.1210/endo.136.6.7750500 [doi]
PST - ppublish
SO  - Endocrinology. 1995 Jun;136(6):2752-9. doi: 10.1210/endo.136.6.7750500.