PMID- 7750569
OWN - NLM
STAT- MEDLINE
DCOM- 19950622
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 364
IP  - 2
DP  - 1995 May 8
TI  - Transforming growth factor beta 1 induces differentiation-specific gene 
      expression in fetal rat brown adipocytes.
PG  - 193-7
AB  - Fetal rat brown adipocytes show a low number of transforming growth factor beta 1 
      (TGF-beta 1) binding sites of high affinity, revealing the presence of type I, II 
      and III TGF-beta 1 receptors and a minor-labeled species of approximately 140 
      kDa. The culture of cells in the presence of TGF-beta 1 induced the expression of 
      the tissue-specific gene uncoupling protein in a dose- and time-dependent manner. 
      In addition, TGF-beta 1 up-regulates the expression of genes involved in 
      adipogenesis such as fatty acid synthase, glycerol 3-phosphate dehydrogenase, 
      malic enzyme and glucose 6-phosphate dehydrogenase, as well as induces the 
      expression of fibronectin (specific target gene for TGF-beta 1). Our results 
      suggest that TGF-beta 1 is a major signal involved in initiating and/or 
      maintaining the thermogenic and adipogenic differentiation of rat fetal brown 
      adipocytes.
FAU - Teruel, T
AU  - Teruel T
AD  - Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, 
      Universidad Complutense, Madrid, Spain.
FAU - Valverde, A M
AU  - Valverde AM
FAU - Benito, M
AU  - Benito M
FAU - Lorenzo, M
AU  - Lorenzo M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Carrier Proteins)
RN  - 0 (Fibronectins)
RN  - 0 (Ion Channels)
RN  - 0 (Membrane Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Uncoupling Agents)
RN  - 0 (Uncoupling Protein 1)
SB  - IM
MH  - Adipose Tissue, Brown/cytology/*drug effects/metabolism
MH  - Animals
MH  - Carrier Proteins/genetics
MH  - Cell Differentiation/drug effects/genetics
MH  - Cells, Cultured
MH  - Fetus
MH  - Fibronectins/genetics
MH  - Gene Expression/drug effects
MH  - Ion Channels
MH  - Kinetics
MH  - Lipid Metabolism
MH  - Membrane Proteins/genetics
MH  - Mitochondrial Proteins
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Receptors, Transforming Growth Factor beta/drug effects/metabolism
MH  - Transforming Growth Factor beta/metabolism/*pharmacology
MH  - Uncoupling Agents/metabolism
MH  - Uncoupling Protein 1
MH  - Up-Regulation/drug effects
EDAT- 1995/05/08 00:00
MHDA- 1995/05/08 00:01
CRDT- 1995/05/08 00:00
PHST- 1995/05/08 00:00 [pubmed]
PHST- 1995/05/08 00:01 [medline]
PHST- 1995/05/08 00:00 [entrez]
AID - 0014-5793(95)00385-M [pii]
AID - 10.1016/0014-5793(95)00385-m [doi]
PST - ppublish
SO  - FEBS Lett. 1995 May 8;364(2):193-7. doi: 10.1016/0014-5793(95)00385-m.