PMID- 7751716
OWN - NLM
STAT- MEDLINE
DCOM- 19950622
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 171
IP  - 5
DP  - 1995 May
TI  - Presence and expression of human herpesvirus 6 in peripheral blood mononuclear 
      cells of S100-positive, T cell chronic lymphoproliferative disease.
PG  - 1351-5
AB  - S100-positive, T cell chronic lymphoproliferative disease (S100-CLPD) is a rare 
      and aggressive hematologic disorder in which the cytoplasmic protein S100 is 
      expressed at high levels in abnormal lymphocytes. Using a DNA probe specific for 
      human herpesvirus 6 (HHV-6), 2 cases of S100-CLPD were examined by DNA and RNA 
      hybridization analysis. The results indicated that HHV-6 DNA was present in 
      uncultured peripheral blood mononuclear cells (PBMC) and that a 1.3-kb viral 
      transcript was expressed in both cases. Analysis of flow-sorted PBMC from 1 case 
      demonstrated that HHV-6 DNA was present exclusively in the S100-positive 
      fraction. Studies using other HHV-6 DNA probes suggested infection with HHV-6 
      variant B in both cases. Hybridization studies using DNA from PBMC of 27 cases of 
      T cell chronic lymphoproliferative disease of other types showed no evidence of 
      HHV-6. These studies suggest a possible specific association of HHV-6 with the 
      unusual disorder S100-CLPD.
FAU - Braun, D K
AU  - Braun DK
AD  - Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 
      48109-0680, USA.
FAU - Pellett, P E
AU  - Pellett PE
FAU - Hanson, C A
AU  - Hanson CA
LA  - eng
GR  - AI-27960/AI/NIAID NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (DNA, Viral)
RN  - 0 (RNA, Viral)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Adult
MH  - DNA, Viral/blood
MH  - Female
MH  - Herpesviridae Infections/*virology
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Leukocytes, Mononuclear/*virology
MH  - Lymphoproliferative Disorders/*virology
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
MH  - RNA, Viral/blood
MH  - S100 Proteins/*analysis
MH  - *T-Lymphocytes
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1093/infdis/171.5.1351 [doi]
PST - ppublish
SO  - J Infect Dis. 1995 May;171(5):1351-5. doi: 10.1093/infdis/171.5.1351.