PMID- 7752464
OWN - NLM
STAT- MEDLINE
DCOM- 19950622
LR  - 20181130
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 53
IP  - 4
DP  - 1995 Apr
TI  - [Parathyroid cells: structure of Ca2+ sensing receptor].
PG  - 805-10
AB  - Using expression in Xenopus oocytes, Brown et al. cloned a bovine parathyroid 
      Ca2+ sensing receptor (BoPCaR1). The 1,085 amino acid membrane protein is 
      included in a class of putative seven transmembrane-spanning structures that 
      activate the phosphoinositol pathway through G proteins. Receptor activation 
      presumably elevates intracellular Ca2+ to inhibit secretion of PTH. BoPCaR1 has a 
      big extracellular domain at the amino terminus. BoPCaR1 is most similar to the 
      metabotropic glutamate receptor. BoPCaR1 mRNA is found in cells that have well 
      known Ca2+ sensing function. Inheritance of one inactive Ca2+ sensing receptor 
      gene causes familial hypocalciuric hypercalcemia (FHH) and autosomal dominant 
      hypocalcemia. Mutations in the extracellular domain and in a portion of the third 
      intracellular loop domain decrease the receptor's sensitivity, causing FHH. 
      Extracellular domain mutations increase the receptor's activity at low Ca2+ 
      concentration to cause autosomal familial hypocalcemia.
FAU - Yoshimoto, K
AU  - Yoshimoto K
AD  - Otsuka Department of Clinical and Molecular Nutrition, School of Medicine, 
      University of Tokushima.
FAU - Saito, S
AU  - Saito S
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Receptors, Cell Surface)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/*metabolism
MH  - Cattle
MH  - Cloning, Molecular
MH  - GTP-Binding Proteins/metabolism
MH  - Genes, Dominant
MH  - Humans
MH  - Hypercalcemia/genetics
MH  - Hypocalcemia/genetics
MH  - Mutation
MH  - Parathyroid Hormone/metabolism
MH  - Receptors, Cell Surface/*chemistry/genetics
MH  - Xenopus
RF  - 10
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1995 Apr;53(4):805-10.