PMID- 7753254
OWN - NLM
STAT- MEDLINE
DCOM- 19950622
LR  - 20180215
IS  - 1660-8151 (Print)
IS  - 1660-8151 (Linking)
VI  - 69
IP  - 3
DP  - 1995
TI  - Clinical course of patients with antineutrophil cytoplasm antibody positive 
      vasculitis after kidney transplantation.
PG  - 234-6
AB  - Four patients with antineutrophil cytoplasm antibody (ANCA)-positive vasculitis 
      were followed over a period from 27 to 54 months after successful kidney 
      transplantation under immunosuppressive treatment with ciclosporine. ANCA titer 
      prior to transplantation was markedly elevated and decreased in 1 of 4 patients 
      under therapy with ciclosporine. Despite adequate ciclosporine blood trough 
      levels, a relapse occurred in 2 patients 18 and 24 months after transplantation 
      but therapy with cyclophosphamide induced remission and no patient lost his graft 
      due to relapse of vasculitis. This observation demonstrates that kidney 
      transplantation may be offered to ANCA-positive patients with end-stage renal 
      disease due to vasculitis. However, patients under ciclosporine therapy are still 
      at risk for the development of relapsing disease and cyclophosphamide has to be 
      added to or substituted in part for standard immunosuppressive therapy in order 
      to reverse clinical symptoms and prevent rapid deterioration of kidney function.
FAU - Grotz, W
AU  - Grotz W
AD  - Department of Medicine, University of Freiburg, Germany.
FAU - Wanner, C
AU  - Wanner C
FAU - Rother, E
AU  - Rother E
FAU - Schollmeyer, P
AU  - Schollmeyer P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Autoantibodies)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Autoantibodies/*analysis
MH  - Cyclosporine/therapeutic use
MH  - Female
MH  - Humans
MH  - *Kidney Transplantation/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Vasculitis/drug therapy/etiology/*immunology
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1159/000188462 [doi]
PST - ppublish
SO  - Nephron. 1995;69(3):234-6. doi: 10.1159/000188462.