PMID- 7753791
OWN - NLM
STAT- MEDLINE
DCOM- 19950616
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 92
IP  - 10
DP  - 1995 May 9
TI  - Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and 
      characterization of gene expression in the developing respiratory and 
      reproductive epithelium.
PG  - 4249-53
AB  - Members of the winged helix/forkhead family of transcription factors are believed 
      to play a role in cell-specific gene expression. A cDNA encoding a member of this 
      family of proteins, termed hepatocyte nuclear factor/forkhead homologue 4 
      (HFH-4), has been isolated from rat lung and rat testis cDNA libraries. This cDNA 
      contains an open reading frame of 421 amino acids with a conserved DNA binding 
      domain and several potential transactivating regions. During murine lung 
      development, a single species of HFH-4-specific transcript (2.4 kb long) is first 
      detected precisely at the start of the late pseudoglandular stage (embryonic day 
      14.5) and, by in situ hybridization, is specifically localized to the proximal 
      pulmonary epithelium. The unique temporal and spatial pattern of HFH-4 gene 
      expression in the developing lung defines this protein as a marker for the 
      initiation of bronchial epithelial cell differentiation and suggests that it may 
      play an important role in cell fate determination during lung development. In 
      addition to expression in the pulmonary epithelium, RNA blot analysis reveals 
      2.4-kb HFH-4 transcripts in the testis and oviduct. By using mice with genetic 
      defects in spermatogenesis, HFH-4 expression in the testis is found to be 
      associated with the appearance of haploid germ cells and in situ hybridization 
      studies indicate that HFH-4 expression is confined to stages I-VII of 
      spermatogenesis. This pattern of HFH-4 gene expression during the early stages of 
      differentiation of haploid germ cells suggests that HFH-4 may play a role in 
      regulating stage-specific gene expression and cell-fate determination during lung 
      development and in spermatogenesis.
FAU - Hackett, B P
AU  - Hackett BP
AD  - Edward Mallinckrodt Department of Pediatrics, Washington University School of 
      Medicine, St. Louis, MO 63110, USA.
FAU - Brody, S L
AU  - Brody SL
FAU - Liang, M
AU  - Liang M
FAU - Zeitz, I D
AU  - Zeitz ID
FAU - Bruns, L A
AU  - Bruns LA
FAU - Gitlin, J D
AU  - Gitlin JD
LA  - eng
SI  - GENBANK/L36388
GR  - F32HL08582/HL/NHLBI NIH HHS/United States
GR  - HL41536/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hepatocyte Nuclear Factor 4)
RN  - 0 (Phosphoproteins)
RN  - 0 (Tcfl4 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Aging/*metabolism
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
MH  - *DNA-Binding Proteins
MH  - Epithelium/metabolism
MH  - Female
MH  - *Gene Expression
MH  - Gene Library
MH  - Hepatocyte Nuclear Factor 4
MH  - Liver/growth & development/metabolism
MH  - Lung/growth & development/*metabolism
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Ovary/growth & development/*metabolism
MH  - *Phosphoproteins
MH  - Rats
MH  - Spermatogenesis
MH  - Testis/growth & development/*metabolism
MH  - Transcription Factors/*biosynthesis/*chemistry
PMC - PMC41921
EDAT- 1995/05/09 00:00
MHDA- 1995/05/09 00:01
PMCR- 1995/11/09
CRDT- 1995/05/09 00:00
PHST- 1995/05/09 00:00 [pubmed]
PHST- 1995/05/09 00:01 [medline]
PHST- 1995/05/09 00:00 [entrez]
PHST- 1995/11/09 00:00 [pmc-release]
AID - 10.1073/pnas.92.10.4249 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1995 May 9;92(10):4249-53. doi: 
      10.1073/pnas.92.10.4249.