PMID- 7753792
OWN - NLM
STAT- MEDLINE
DCOM- 19950616
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 92
IP  - 10
DP  - 1995 May 9
TI  - Mammary tumor suppression by transforming growth factor beta 1 transgene 
      expression.
PG  - 4254-8
AB  - In cell culture, type alpha transforming growth factor (TGF-alpha) stimulates 
      epithelial cell growth, whereas TGF-beta 1 overrides this stimulatory effect and 
      is growth inhibitory. Transgenic mice that overexpress TGF-alpha under control of 
      the mouse mammary tumor virus (MMTV) promoter/enhancer exhibit mammary ductal 
      hyperplasia and stochastic development of mammary carcinomas, a process that can 
      be accelerated by administration of the chemical carcinogen 
      7,12-dimethylbenz[a]anthracene. MMTV-TGF-beta 1 transgenic mice display mammary 
      ductal hypoplasia and do not develop mammary tumors. We report that in 
      crossbreeding experiments involving the production of mice carrying both the 
      MMTV-TGF-beta 1 and MMTV-TGF-alpha transgenes, there is marked suppression of 
      mammary tumor formation and that MMTV-TGF-beta 1 transgenic mice are resistant to 
      7,12-dimethylbenz[a]anthracene-induced mammary tumor formation. These data 
      demonstrate that overexpression of TGF-beta 1 in vivo can markedly suppress 
      mammary tumor development.
FAU - Pierce, D F Jr
AU  - Pierce DF Jr
AD  - Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, 
      TN 37232-2175, USA.
FAU - Gorska, A E
AU  - Gorska AE
FAU - Chytil, A
AU  - Chytil A
FAU - Meise, K S
AU  - Meise KS
FAU - Page, D L
AU  - Page DL
FAU - Coffey, R J Jr
AU  - Coffey RJ Jr
FAU - Moses, H L
AU  - Moses HL
LA  - eng
GR  - CA 42572/CA/NCI NIH HHS/United States
GR  - CA 46413/CA/NCI NIH HHS/United States
GR  - CA 48799/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Transforming Growth Factor beta)
RN  - 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
RN  - 9004-22-2 (Globins)
SB  - IM
MH  - 9,10-Dimethyl-1,2-benzanthracene
MH  - Adenocarcinoma/chemically induced/pathology/prevention & control
MH  - Adenoma/chemically induced/pathology/prevention & control
MH  - Aging
MH  - Animals
MH  - Crosses, Genetic
MH  - Enhancer Elements, Genetic
MH  - Exons
MH  - Female
MH  - Globins/biosynthesis/genetics
MH  - Male
MH  - Mammary Glands, Animal/cytology/*pathology
MH  - Mammary Neoplasms, Experimental/chemically induced/pathology/*prevention & 
      control
MH  - Mammary Tumor Virus, Mouse/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Mice, Transgenic
MH  - Polymerase Chain Reaction
MH  - Promoter Regions, Genetic
MH  - Rabbits
MH  - Transforming Growth Factor beta/*biosynthesis
PMC - PMC41922
EDAT- 1995/05/09 00:00
MHDA- 2001/03/28 10:01
PMCR- 1995/11/09
CRDT- 1995/05/09 00:00
PHST- 1995/05/09 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1995/05/09 00:00 [entrez]
PHST- 1995/11/09 00:00 [pmc-release]
AID - 10.1073/pnas.92.10.4254 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1995 May 9;92(10):4254-8. doi: 10.1073/pnas.92.10.4254.