PMID- 7755916
OWN - NLM
STAT- MEDLINE
DCOM- 19950627
LR  - 20131121
IS  - 0269-9370 (Print)
IS  - 0269-9370 (Linking)
VI  - 9
IP  - 3
DP  - 1995 Mar
TI  - Concordance of human leukocyte antigen haplotype-sharing, CD4 decline and AIDS in 
      hemophilic siblings. Multicenter Hemophilia Cohort and Hemophilia Growth and 
      Development Studies.
PG  - 275-80
AB  - OBJECTIVE: To assess the association between human leukocyte antigen (HLA) 
      haplotypes and the incidence rates of CD4 decline to < 20% and to AIDS. DESIGN: 
      Retrospective cohort study of 95 HIV-1-infected hemophilic sibling pairs. 
      METHODS: HLA haplotype-sharing between siblings was assigned on the basis of 
      serologic typing of HLA class I alleles and molecular typing of HLA class II 
      alleles. Concordance of time to CD4 decline to < 20% and to AIDS within and 
      between sibling pairs was assessed by analysis of variance models and 
      calculations of intraclass correlation coefficients. The age-adjusted relative 
      risks of these two endpoints for unique class II haplotypes were determined from 
      proportional hazards models. RESULTS: Sibling pairs sharing one or two haplotypes 
      were significantly concordant in CD4 decline and AIDS status within 5 years of 
      seroconversion. No concordance was found in pairs sharing zero haplotypes. At 
      6-10 years after seroconversion, significant concordance of these two endpoints 
      was also observed in the pairs sharing one haplotype. The concordant results were 
      not explained by the use of zidovudine within the pairs. Among the individuals in 
      this cohort, the relative hazards for CD4 decline to < 20% and for AIDS were 
      significantly elevated for one class II haplotype (DQB1*0501, DQA1*0101, 
      DRB1*0101). In addition, the risk for AIDS was significantly increased for two 
      other class II haplotypes (DQB1*0603, DQA1*0103, DRB1*1300, DRB3*0202 and 
      DQB1*0301, DQA1*0501, DRB1*1400, DRB3*0202) and significantly decreased for one 
      haplotype (DQB1*0302, DQA1*0301, DRB1*0401, DRB4*0101). CONCLUSIONS: These data 
      demonstrate that HIV-1 disease progression is associated with the genes in the 
      major histocompatibility complex that regulate the host's immune response.
FAU - Kroner, B L
AU  - Kroner BL
AD  - Epidemiologic and Medical Studies Program, Research Triangle Institute, 
      Rockville, MD 20852, USA.
FAU - Goedert, J J
AU  - Goedert JJ
FAU - Blattner, W A
AU  - Blattner WA
FAU - Wilson, S E
AU  - Wilson SE
FAU - Carrington, M N
AU  - Carrington MN
FAU - Mann, D L
AU  - Mann DL
LA  - eng
GR  - N01-CP-33002/CP/NCI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 4B9XT59T7S (Zidovudine)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*complications/drug 
      therapy/epidemiology/physiopathology
MH  - Age Factors
MH  - Analysis of Variance
MH  - *CD4 Lymphocyte Count
MH  - Cohort Studies
MH  - Disease Progression
MH  - Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - HIV Seropositivity
MH  - *HIV-1
MH  - Haplotypes
MH  - Hemophilia A/*complications
MH  - Histocompatibility Antigens Class I/*blood
MH  - Histocompatibility Antigens Class II/*blood
MH  - Humans
MH  - Incidence
MH  - *Nuclear Family
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Zidovudine/therapeutic use
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
PST - ppublish
SO  - AIDS. 1995 Mar;9(3):275-80.