PMID- 7756626
OWN - NLM
STAT- MEDLINE
DCOM- 19950623
LR  - 20161123
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 6
IP  - 2
DP  - 1995 Jan 26
TI  - AF64A disrupts retrieval processes in long-term memory of mice.
PG  - 349-52
AB  - Intracerebroventricular (i.c.v.) injection of ethylcholine mustard aziridinium 
      ion (AF64A) in mice caused a reversible impairment of retrieval processing in 
      long-term memory. After long retention intervals (1-3 weeks), AF64A-treated mice 
      demonstrated marked impairment of behavioural performance previously acquired in 
      a complex multiple maze task. This behavioural deficit was dose dependently 
      ameliorated by the administration of oxotremorine. In parallel with the 
      behavioural deficit, AF64A selectively decreased acetylcholine (ACh) levels in 
      the hippocampus. These findings suggest that the reversible behavioural deficit 
      induced by AF64A should be regarded as a retrieval failure in long-term memory, 
      and not as a retention failure. This failure was largely associated with 
      dysfunction of the cholinergic neuronal system in the hippocampus.
FAU - Murai, S
AU  - Murai S
AD  - Department of Pharmacology, School of Dentistry, Iwate Medical University, 
      Morioka, Japan.
FAU - Saito, H
AU  - Saito H
FAU - Masuda, Y
AU  - Masuda Y
FAU - Odashima, J
AU  - Odashima J
FAU - Itoh, T
AU  - Itoh T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Aziridines)
RN  - 0 (Neurotoxins)
RN  - A668M9E227 (ethylcholine aziridinium)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Animals
MH  - Aziridines/*pharmacology
MH  - Choline/*analogs & derivatives/pharmacology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*chemically induced
MH  - Mental Processes/*drug effects
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Neurotoxins/*pharmacology
MH  - Time Factors
EDAT- 1995/01/26 00:00
MHDA- 1995/01/26 00:01
CRDT- 1995/01/26 00:00
PHST- 1995/01/26 00:00 [pubmed]
PHST- 1995/01/26 00:01 [medline]
PHST- 1995/01/26 00:00 [entrez]
PST - ppublish
SO  - Neuroreport. 1995 Jan 26;6(2):349-52.