PMID- 7757166
OWN - NLM
STAT- MEDLINE
DCOM- 19950629
LR  - 20190503
IS  - 1351-0711 (Print)
IS  - 1470-7926 (Electronic)
IS  - 1351-0711 (Linking)
VI  - 52
IP  - 2
DP  - 1995 Feb
TI  - Allergy to laboratory animals: a follow up study of its incidence and of the 
      influence of atopy and pre-existing sensitisation on its development.
PG  - 129-33
AB  - OBJECTIVES: To investigate the incidence of allergy to laboratory animals (ALA) 
      during the first two years of employment, and to study the effect on ALA of atopy 
      and sensitisation. METHODS: A follow up prospective study of ALA at the Zeneca 
      (formerly ICI) Research Laboratories. RESULTS: The incidence of the disease 
      during the first year of employment has remained at about 10% since the 
      mid-1980s. This compares with an incidence of 37% in the early 1980s. The 
      reduction in incidence and its maintenance at a lower level is thought to be due 
      to the introduction and management of improved engineering controls, working 
      practices, and educational programmes designed to reduce exposure to allergens 
      from laboratory animals. The underlying incidence of immunological sensitisation 
      to animals (the presence of immunoglobulin E (IgE) antibodies to animal 
      allergens) is much higher (40% after one and 53% after two years of exposure). 
      Both atopic diathesis and presensitisation to laboratory animals increased the 
      likelihood that a person would develop ALA. CONCLUSION: Neither factor predicted 
      the disease accurately so their use should be restricted to the identification of 
      people who may be more susceptible to the development of ALA (and thus who may 
      need to pay particular attention to the use of personal protective equipment) 
      rather than to their exclusion.
FAU - Botham, P A
AU  - Botham PA
AD  - Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire.
FAU - Lamb, C T
AU  - Lamb CT
FAU - Teasdale, E L
AU  - Teasdale EL
FAU - Bonner, S M
AU  - Bonner SM
FAU - Tomenson, J A
AU  - Tomenson JA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Occup Environ Med
JT  - Occupational and environmental medicine
JID - 9422759
SB  - IM
MH  - Animals
MH  - *Animals, Laboratory
MH  - England/epidemiology
MH  - Follow-Up Studies
MH  - Guinea Pigs
MH  - Humans
MH  - Hypersensitivity/*epidemiology/etiology
MH  - Immunologic Tests
MH  - Incidence
MH  - Medical Laboratory Personnel
MH  - Mice
MH  - Occupational Diseases/*epidemiology/etiology
MH  - Prospective Studies
MH  - Rabbits
MH  - Rats
MH  - Swine
MH  - Time Factors
PMC - PMC1128167
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
PMCR- 1995/02/01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
PHST- 1995/02/01 00:00 [pmc-release]
AID - 10.1136/oem.52.2.129 [doi]
PST - ppublish
SO  - Occup Environ Med. 1995 Feb;52(2):129-33. doi: 10.1136/oem.52.2.129.