PMID- 7757292
OWN - NLM
STAT- MEDLINE
DCOM- 19950628
LR  - 20200304
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 426
IP  - 2
DP  - 1995
TI  - Lack of allelic loss at the multiple endocrine neoplasia type 1 (MEN-1) gene 
      locus in a pancreatic ductal (non-endocrine) adenocarcinoma of a patient with the 
      MEN-1 syndrome.
PG  - 203-8
AB  - The gene responsible for multiple endocrine neoplasia type I (MEN-1) syndrome has 
      been mapped to chromosome 11q13. It appears to function as a tumour-suppressor 
      gene analogous to that for retinoblastoma and allelic losses involving the 
      wild-type of the MEN-1 allele have been found in parathyroid and pancreatic 
      endocrine tumours of MEN-1 patients. No genetic information has been provided so 
      far on non-endocrine malignancies that may occur in MEN-1 patients. A case of 
      exocrine pancreatic adenocarcinoma presenting as the terminal event in a woman 
      with a long standing history of MEN-1 syndrome and multiple endocrine tumours of 
      the pancreas was investigated for possible allelic losses at the MEN-1 gene locus 
      using restriction fragment length polymorphisms (RFLPs) closely linked to the 
      MEN-1 gene and polymerase chain reaction (PCR) for D11S533 locus. No allelic 
      losses were found in tumour tissue with two informative RFLPs (D11S97, D11S146) 
      or with PCR analysis. These findings suggest that the MEN-1 gene does not confer 
      a predisposition to develop tumours other than those that typify the syndrome.
FAU - Bordi, C
AU  - Bordi C
AD  - Institute of Anatomic Pathology, University of Parma, Italy.
FAU - Falchetti, A
AU  - Falchetti A
FAU - Azzoni, C
AU  - Azzoni C
FAU - D'Adda, T
AU  - D'Adda T
FAU - Morelli, A
AU  - Morelli A
FAU - Peracchia, A
AU  - Peracchia A
FAU - Brandi, M L
AU  - Brandi ML
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
SB  - IM
MH  - Adenocarcinoma/*genetics/secondary
MH  - Aged
MH  - *Alleles
MH  - Blotting, Southern
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/secondary
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Pancreatic Neoplasms/*genetics
MH  - Polymerase Chain Reaction
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/BF00192643 [doi]
PST - ppublish
SO  - Virchows Arch. 1995;426(2):203-8. doi: 10.1007/BF00192643.