PMID- 7759461
OWN - NLM
STAT- MEDLINE
DCOM- 19950623
LR  - 20190920
IS  - 0277-0903 (Print)
IS  - 0277-0903 (Linking)
VI  - 32
IP  - 3
DP  - 1995
TI  - Effect of interferon-alpha therapy on serum IgE, IL-4, and sCD23 levels in 
      childhood asthma.
PG  - 215-20
AB  - Seven children with asthma were included in a trial of recombinant 
      interferon-alpha 2a (rIFN-alpha 2a). Patients received either 2 million U/m2 
      rIFN-alpha 2a (n = 4) or placebo (n = 3) three times a week for 4 weeks. 
      Pulmonary function test, peak expiratory flow rates (PEFR), and clinical symptom 
      scores were monitored throughout the trial. Serum interleukin-4, soluble 
      low-affinity receptor for IgE Fc epsilon RII/CD23 (sCD23), and immunoglobulin E 
      (IgE) levels were measured at the beginning of the trial, and at the second week, 
      fourth week, and sixth week. Compared with placebo, rIFN-alpha 2a therapy did not 
      result in a significant change in the above-mentioned parameters. Further studies 
      with a larger number of patients are needed to draw firmer conclusions in regard 
      to efficacy of rIFN-alpha 2a therapy in childhood asthma.
FAU - Basaran, M M
AU  - Basaran MM
AD  - Division of Pediatric Allergy-Immunology, Marmara University Hospital, Istanbul, 
      Turkey.
FAU - Barlan, I B
AU  - Barlan IB
FAU - Tukenmez, F
AU  - Tukenmez F
FAU - Dai, A
AU  - Dai A
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Interferon alpha-2)
RN  - 0 (Interferon-alpha)
RN  - 0 (Receptors, IgE)
RN  - 0 (Recombinant Proteins)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/blood/physiopathology/*therapy
MH  - Child
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Interferon alpha-2
MH  - Interferon-alpha/*therapeutic use
MH  - Interleukin-4/*blood
MH  - Male
MH  - Pilot Projects
MH  - Receptors, IgE/*analysis
MH  - Recombinant Proteins
MH  - Time Factors
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.3109/02770909509089510 [doi]
PST - ppublish
SO  - J Asthma. 1995;32(3):215-20. doi: 10.3109/02770909509089510.