PMID- 7759957
OWN - NLM
STAT- MEDLINE
DCOM- 19950628
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 57
IP  - 5
DP  - 1995 May
TI  - Matrix metalloproteinases and processing of pro-TNF-alpha.
PG  - 774-7
AB  - Tumor necrosis factor-alpha (TNF-alpha) is released from a cell membrane-anchored 
      precursor by proteolytic cleavage. We have shown that broad spectrum synthetic 
      inhibitors of matrix metalloproteinases (MMPs) prevent the processing of the TNF 
      precursor but do not inhibit the release of other cytokines. Purified MMPs, 
      stromelysin, matrilysin, collagenase, and the gelatinases can all cleave a 
      recombinant pro-TNF substrate to yield mature TNF. MMP inhibitors prevent the 
      rise in blood levels of TNF after endotoxin administration in rats and are 
      effective in animal models of inflammatory disease such as adjuvant arthritis. 
      Drugs that inhibit MMP action and TNF release show great promise for the 
      treatment of autoimmune inflammatory diseases.
FAU - Gearing, A J
AU  - Gearing AJ
AD  - Neures Ltd., Abingdon, Oxon, UK.
FAU - Beckett, P
AU  - Beckett P
FAU - Christodoulou, M
AU  - Christodoulou M
FAU - Churchill, M
AU  - Churchill M
FAU - Clements, J M
AU  - Clements JM
FAU - Crimmin, M
AU  - Crimmin M
FAU - Davidson, A H
AU  - Davidson AH
FAU - Drummond, A H
AU  - Drummond AH
FAU - Galloway, W A
AU  - Galloway WA
FAU - Gilbert, R
AU  - Gilbert R
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Peptides)
RN  - 0 (Protein Precursors)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Gene Expression/drug effects
MH  - Humans
MH  - Metalloendopeptidases/*physiology
MH  - Molecular Sequence Data
MH  - Monocytes/metabolism
MH  - Peptides/chemistry
MH  - Protein Precursors/metabolism
MH  - Protein Processing, Post-Translational
MH  - Recombinant Fusion Proteins/metabolism
MH  - Tumor Necrosis Factor-alpha/*metabolism
RF  - 26
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1002/jlb.57.5.774 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1995 May;57(5):774-7. doi: 10.1002/jlb.57.5.774.