PMID- 7760403
OWN - NLM
STAT- MEDLINE
DCOM- 19950627
LR  - 20190711
IS  - 0022-5282 (Print)
IS  - 0022-5282 (Linking)
VI  - 38
IP  - 5
DP  - 1995 May
TI  - The effect of heat load and dehydration on hypertonic saline solution treatment 
      of uncontrolled hemorrhagic shock.
PG  - 747-52
AB  - Hypertonic saline solution treatment of uncontrolled hemorrhagic shock (UCHS) 
      leads to increased bleeding from injured vessels, fall in arterial blood 
      pressure, and increased mortality. The effect of dehydration induced by either 
      water deprivation or heating on this response was studied in rats. The animals 
      were divided into four groups: group 1 (n = 32), normal rats; group 2 (n = 30), 
      water deprivation for 12 hours; group 3 (n = 30), heating at 37 degrees C for 5 
      hours; and group 4 (n = 30), heating as in group 3 and water deprivation as in 
      group 2. UCHS was induced in all rats by 20% resection of the animals' tail. The 
      rats were then divided into four treatment subgroups: group a was untreated, 
      group b was treated after 15 minutes with 5 mL/kg NaCl 7.5% hypertonic saline 
      (HTS), group c was treated after 15 minutes with 41.5 mL/kg NaCl 0.9% large 
      volume normal saline (LNS) and group d was treated after 15 minutes with HTS + 
      LNS. Tail resection in group 1a resulted in bleeding of 4.9 +/- 0.3 mL, and fall 
      in mean arterial pressure (MAP) to 50 +/- 3 mm Hg (p < 0.001). Blood loss and 
      fall in hematocrit in groups 2, 3, and 4 was significantly lower than in group 1. 
      The fall in MAP and pulse rate was similar in all four groups.(ABSTRACT TRUNCATED 
      AT 250 WORDS)
FAU - Krausz, M M
AU  - Krausz MM
AD  - Dept. of Surgery B, Carmel Medical Center, Haifa, Israel.
FAU - Klemm, O
AU  - Klemm O
FAU - Amstislavsky, T
AU  - Amstislavsky T
FAU - Horovitz, M
AU  - Horovitz M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
RN  - 0 (Saline Solution, Hypertonic)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Body Weight
MH  - Dehydration/*complications
MH  - Hematocrit
MH  - Hemorrhage/physiopathology
MH  - *Hot Temperature
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Resuscitation
MH  - Saline Solution, Hypertonic/*therapeutic use
MH  - Shock, Hemorrhagic/blood/complications/physiopathology/*therapy
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1097/00005373-199505000-00012 [doi]
PST - ppublish
SO  - J Trauma. 1995 May;38(5):747-52. doi: 10.1097/00005373-199505000-00012.