PMID- 7762736
OWN - NLM
STAT- MEDLINE
DCOM- 19950623
LR  - 20071114
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 19 Suppl 1
DP  - 1995
TI  - Clinicopathologic aspects of gastric neuroendocrine tumors.
PG  - S20-9
AB  - The major clinicopathologic aspects of 55 gastric neuroendocrine tumors were 
      analyzed. Forty-six of 55 cases were well-differentiated tumors and 9 were poorly 
      differentiated gastric neuroendocrine carcinomas. Well-differentiated gastric 
      neuroendocrine tumors comprised 1 gastrinoma and 45 enterochromaffin-like 
      (ECL)-cell tumors. ECL tumors were grouped depending on their clinical 
      background. Type 1, associated with chronic atrophic gastritis of the acidopeptic 
      mucosa (A-CAG), included 28 cases with tumor growths mainly restricted to the 
      mucosa and submucosa, with no metastasis. Type 2, associated with hypertrophic 
      gastropathy, included seven cases, six of which were associated with 
      Zollinger-Ellison syndrome (ZES) and multiple endocrine neoplasia type 1 (MEN-1), 
      including two cases with local metastasis. Type 3, not associated with any 
      significant clinicopathologic condition (sporadic), included 10 cases, 7 of which 
      were deeply invasive and 5 metastatic. The nine gastric neuroendocrine carcinomas 
      were highly aggressive metastatic tumors. At follow-up, no tumor-related death 
      was observed for type 1 and type 2 ECL tumors. Type 3 (sporadic) ECL tumors were 
      fatal in 3 of 10 cases, and 6 of 9 patients with gastric neuroendocrine 
      carcinomas died of their tumor disease. It is concluded that type 1 and type 2 
      well-differentiated ECL tumors are benign or low-grade tumors, whereas type 3 
      well-differentiated ECL tumors and the poorly differentiated neuroendocrine 
      carcinomas are malignant neoplasms.
FAU - Rindi, G
AU  - Rindi G
AD  - Gastroenterology Division, New England Medical Center, Boston, Massachusetts, 
      USA.
LA  - eng
GR  - TW04781/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Gastrins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gastrins/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuroendocrine Tumors/metabolism/*pathology
MH  - Stomach Neoplasms/metabolism/*pathology
RF  - 71
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - Am J Surg Pathol. 1995;19 Suppl 1:S20-9.