PMID- 7766992 OWN - NLM STAT- MEDLINE DCOM- 19950705 LR - 20190904 IS - 0938-8990 (Print) IS - 0938-8990 (Linking) VI - 6 IP - 2 DP - 1995 Feb TI - Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. PG - 111-3 AB - The adenylyl cyclases (AC) act as second messengers in regulatory processes in the central nervous system. They might be involved in the pathophysiology of diseases, but their biological function is unknown, except for AC type I, which has been implicated in learning and memory. We previously mapped the gene encoding AC I to human Chromosome (Chr) 7p12. In this study we report the mapping of the adenylyl cyclase genes type I-VI to mouse chromosomes by fluorescence in situ hybridization (FISH): Adcy1 to Chr 11A2, Adcy2 to 13C1, Adcy3 to 12A-B, Adcy4 to 14D3, Adcy5 to 16B5, and Adcy6 to 15F. We also confirmed previously reported mapping results of the corresponding human loci ADCY2, ADCY3, ADCY5, and ADCY6 to human chromosomes and, in addition, determined the chromosomal location of ADCY4 to human Chr 14q11.2. The mapping data confirm known areas of conservation between mouse and human chromosomes. FAU - Edelhoff, S AU - Edelhoff S AD - Department of Pathology, University of Washington, School of Medicine, Seattle 98195, USA. FAU - Villacres, E C AU - Villacres EC FAU - Storm, D R AU - Storm DR FAU - Disteche, C M AU - Disteche CM LA - eng GR - NS01653/NS/NINDS NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Mamm Genome JT - Mammalian genome : official journal of the International Mammalian Genome Society JID - 9100916 RN - 0 (Isoenzymes) RN - EC 4.6.1.1 (Adenylyl Cyclases) SB - IM GS - ADCY1 GS - ADCY2 GS - ADCY3 GS - ADCY4 GS - ADCY5 GS - ADCY6 GS - adcy1 GS - adcy2 GS - adcy3 GS - adcy4 GS - adcy5 GS - adcy6 MH - Adenylyl Cyclases/classification/*genetics MH - Animals MH - *Chromosome Mapping MH - Chromosomes, Human, Pair 14 MH - Chromosomes, Human, Pair 7 MH - Dogs MH - *Genes MH - Humans MH - Isoenzymes/classification/*genetics MH - Male MH - Mice/*genetics MH - Mice, Inbred C57BL MH - *Multigene Family MH - Species Specificity EDAT- 1995/02/01 00:00 MHDA- 1995/02/01 00:01 CRDT- 1995/02/01 00:00 PHST- 1995/02/01 00:00 [pubmed] PHST- 1995/02/01 00:01 [medline] PHST- 1995/02/01 00:00 [entrez] AID - 10.1007/BF00303253 [doi] PST - ppublish SO - Mamm Genome. 1995 Feb;6(2):111-3. doi: 10.1007/BF00303253.