PMID- 7768367
OWN - NLM
STAT- MEDLINE
DCOM- 19950630
LR  - 20190707
IS  - 0016-5085 (Print)
IS  - 0016-5085 (Linking)
VI  - 108
IP  - 6
DP  - 1995 Jun
TI  - Determinants of metastatic rate and survival in patients with Zollinger-Ellison 
      syndrome: a prospective long-term study.
PG  - 1637-49
AB  - BACKGROUND/AIMS: It is unclear whether tumor location, size, or the presence of 
      multiple endocrine neoplasia type 1 (MEN-1) alters metastatic rate and survival 
      in patients with pancreatic endocrine tumors. The purpose of this study was to 
      determine the prognostic factors of survival and metastatic rate in patients with 
      Zollinger-Ellison syndrome (ZES). METHODS: Data were analyzed from 185 
      consecutive patients with ZES who were followed up prospectively. RESULTS: Liver 
      metastases were present in 24% of patients and correlated with the size of the 
      primary tumor. Duodenal tumors were smaller than pancreatic tumors. Liver 
      metastases occurred more often (P < 0.00001) with pancreatic than duodenal 
      tumors, whereas the metastatic rate to lymph nodes was not different. Survival of 
      patients with liver but not lymph node metastases was shortened. In patients with 
      sporadic ZES, liver metastases were more common during the initial evaluation and 
      survival was decreased compared with patients with MEN-1; however, during 
      follow-up, an equal percentage of patients with and without MEN-1 developed liver 
      metastases. CONCLUSIONS: Survival was primarily determined by the presence of 
      liver metastases. The frequency of liver metastases depends on the size and 
      location of the primary tumor and on the presence of MEN-1 at the initial 
      presentation. Metastases to the lymph nodes do not depend on these factors. A 
      benign and malignant form of ZES exists.
FAU - Weber, H C
AU  - Weber HC
AD  - Digestive Diseases Branch, National Institute of Diabetes and Digestive and 
      Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
FAU - Venzon, D J
AU  - Venzon DJ
FAU - Lin, J T
AU  - Lin JT
FAU - Fishbein, V A
AU  - Fishbein VA
FAU - Orbuch, M
AU  - Orbuch M
FAU - Strader, D B
AU  - Strader DB
FAU - Gibril, F
AU  - Gibril F
FAU - Metz, D C
AU  - Metz DC
FAU - Fraker, D L
AU  - Fraker DL
FAU - Norton, J A
AU  - Norton JA
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Follow-Up Studies
MH  - Humans
MH  - Liver Neoplasms/secondary
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/mortality
MH  - Prospective Studies
MH  - Survival Rate
MH  - Zollinger-Ellison Syndrome/*mortality/pathology
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - S0016508595001740 [pii]
AID - 10.1016/0016-5085(95)90124-8 [doi]
PST - ppublish
SO  - Gastroenterology. 1995 Jun;108(6):1637-49. doi: 10.1016/0016-5085(95)90124-8.