PMID- 7769308
OWN - NLM
STAT- MEDLINE
DCOM- 19950705
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 171
IP  - 6
DP  - 1995 Jun
TI  - Monocyte chemotactic protein 1 is released during lethal and sublethal bacteremia 
      in baboons.
PG  - 1640-2
AB  - The chemokine monocyte chemotactic protein 1 (MCP-1) is a cytokine with 
      chemotactic activity specific for mononuclear phagocytes. To investigate the 
      possible involvement of MCP-1 in the pathogenesis of sepsis, its course was 
      studied in baboons challenged intravenously with a sublethal or lethal dose of 
      Escherichia coli. Levels of MCP-1 started to increase in both groups of animals 2 
      h after injection of E. coli, reaching peak levels 4 and 6 h after a sublethal 
      (186 +/- 21 ng/mL) or a lethal (213 +/- 24 ng/mL) dose, respectively. Levels of 
      MCP-1 correlated significantly with plasma levels of another chemokine, 
      interleukin-8 (IL-8; r = .826. P < .001), suggesting that common stimuli mediate 
      the release of both cytokines in this model.
FAU - Jansen, P M
AU  - Jansen PM
AD  - Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, 
      University of Amsterdam.
FAU - van Damme, J
AU  - van Damme J
FAU - Put, W
AU  - Put W
FAU - de Jong, I W
AU  - de Jong IW
FAU - Taylor, F B Jr
AU  - Taylor FB Jr
FAU - Hack, C E
AU  - Hack CE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Animals
MH  - Bacteremia/*blood
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*blood
MH  - Cytokines/*blood
MH  - Escherichia coli Infections/*blood
MH  - Interleukin-8/blood
MH  - Papio
MH  - Time Factors
EDAT- 1995/06/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 10.1093/infdis/171.6.1640 [doi]
PST - ppublish
SO  - J Infect Dis. 1995 Jun;171(6):1640-2. doi: 10.1093/infdis/171.6.1640.