PMID- 7770957
OWN - NLM
STAT- MEDLINE
DCOM- 19950630
LR  - 20190913
IS  - 0191-3123 (Print)
IS  - 0191-3123 (Linking)
VI  - 19
IP  - 1
DP  - 1995 Jan-Feb
TI  - Electron microscopic studies of peripheral blood mononuclear cells in chronic 
      type C hepatitis treated with interferon-alpha.
PG  - 1-8
AB  - Electron microscopic studies of peripheral blood mononuclear cells (PBMC) in 
      chronic type C hepatitis revealed several interesting structures after 
      interferon-alpha (IFN-alpha) therapy. Fifteen of 20 patients were treated with 
      IFN-alpha. Tubuloreticular inclusions (TRI) were observed in only one patient who 
      did not receive therapy. In contrast, TRI were observed in 10 of 15 (66.7%) 
      patients who underwent the therapy for 2 weeks to 6 months. Cylindric confronting 
      cisternae (CCC) were identified in the cytoplasm of PBMC in 4 of 16 (25%) 
      patients who underwent the therapy. CCC were found only after IFN-alpha therapy. 
      The appearance of both TRI and CCC in the PBMC was significantly correlated to 
      IFN-alpha therapy. Although there is little evidence about the morphogenesis of 
      TRI and CCC, these structures may be a host response to IFN-alpha induced by 
      hepatitis C virus infection.
FAU - Watanabe, S
AU  - Watanabe S
AD  - Third Department of Internal Medicine, Kagawa Medical School, Japan.
FAU - Ito, T
AU  - Ito T
FAU - Shirai, M
AU  - Shirai M
FAU - Arima, K
AU  - Arima K
FAU - Nishioka, M
AU  - Nishioka M
FAU - Saito, T
AU  - Saito T
FAU - Ohbayashi, M
AU  - Ohbayashi M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ultrastruct Pathol
JT  - Ultrastructural pathology
JID - 8002867
RN  - 0 (Interferon-alpha)
SB  - IM
MH  - Adult
MH  - Female
MH  - Hepatitis C/blood/pathology/*therapy
MH  - Humans
MH  - Inclusion Bodies/*ultrastructure
MH  - Interferon-alpha/*therapeutic use
MH  - Leukocyte Count
MH  - Leukocytes, Mononuclear/*ultrastructure
MH  - Liver/pathology
MH  - Male
MH  - Microscopy, Electron
MH  - Microscopy, Immunoelectron
MH  - Middle Aged
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.3109/01913129509014597 [doi]
PST - ppublish
SO  - Ultrastruct Pathol. 1995 Jan-Feb;19(1):1-8. doi: 10.3109/01913129509014597.