PMID- 7771471
OWN - NLM
STAT- MEDLINE
DCOM- 19950703
LR  - 20190821
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 49
IP  - 2
DP  - 1995 Jun
TI  - Treatment of platelet alloimmunization with intravenous immunoglobulin in a child 
      with aplastic anemia.
PG  - 165-6
AB  - A 9-year-old girl with severe refractory aplastic anemia had become refractory to 
      platelet transfusion due to platelet alloimmunization. As a result, a huge right 
      parieto-temporo-occipital cerebral hematoma and a subarachnoid hemorrhage 
      subsequently occurred. Intravenous immunoglobulin (IVIG) (Green Cross, Taiwan) at 
      a dose of 0.4 g/kg/day for 5 days, followed by another 3 doses during the 
      following 5 days, and combined with large-dose platelet transfusions effectively 
      controlled the bleeding by elevating the platelet count to above 100 x 10(3)/mm3. 
      The patient soon recovered with only a mild sequela. Two months later, because of 
      multiple caries and a periodontal abscess, dental extraction needed to be 
      performed. IVIG (0.4 g/kg/day x 6 days) enabled surgery to proceed by elevating 
      the platelet count to above 55 x 10(3)/mm3, and no bleeding complications 
      occurred during or after the procedure. The potential benefit of high-dose IVIG 
      in modulating platelet alloimmunization is a result of increasing the survival of 
      transfused platelets. Thus, this therapy is recommended when patients with 
      platelet alloimmunization have critical bleeding episodes or undergo surgical 
      procedures.
FAU - Chen, S H
AU  - Chen SH
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan, Republic of 
      China.
FAU - Liang, D C
AU  - Liang DC
FAU - Lin, M
AU  - Lin M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (Antigens, Human Platelet)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Anemia, Aplastic/complications/*immunology
MH  - Antibody Formation
MH  - Antigens, Human Platelet/*immunology
MH  - Cerebral Hemorrhage/complications
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunization
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Isoantibodies/*immunology
MH  - Platelet Transfusion
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 10.1002/ajh.2830490213 [doi]
PST - ppublish
SO  - Am J Hematol. 1995 Jun;49(2):165-6. doi: 10.1002/ajh.2830490213.