PMID- 7773190
OWN - NLM
STAT- MEDLINE
DCOM- 19950710
LR  - 20131121
IS  - 1039-9712 (Print)
IS  - 1039-9712 (Linking)
VI  - 35
IP  - 3
DP  - 1995 Mar
TI  - Positive regulatory role of cAMP on alkaline phosphatase activity and 
      proliferation of mitogen stimulated B lymphocytes.
PG  - 535-40
AB  - Effect of dibutyryl cyclic adenosine monophosphate (dbt cAMP) on alkaline 
      phosphatase (APase) of mitogen stimulated murine B lymphocytes was studied. 
      Addition of dbtcAMP to lipopolysaccharide (LPS) stimulated B cells enhanced APase 
      activity in a dose dependent and synergistic manner. dbtcAMP also stimulated the 
      proliferative response of LPS treated B lymphocytes. On the other hand, when B 
      lymphocytes stimulated with anti-immunoglobulin (anti-Ig) were treated with 
      dbtcAMP neither DNA synthesis nor APase activity was enhanced. These results 
      suggest that cAMP is a potent synergistic activator of APase in B lymphocytes 
      committed to proliferation.
FAU - Kasyapa, C S
AU  - Kasyapa CS
AD  - Department of Biochemistry, School of Life Sciences University of Hyderabad, 
      India.
FAU - Ramanadham, M
AU  - Ramanadham M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biochem Mol Biol Int
JT  - Biochemistry and molecular biology international
JID - 9306673
RN  - 0 (Lipopolysaccharides)
RN  - 63X7MBT2LQ (Bucladesine)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
SB  - IM
MH  - Alkaline Phosphatase/*metabolism
MH  - Animals
MH  - B-Lymphocytes/enzymology/*physiology
MH  - Bucladesine/pharmacology
MH  - Cyclic AMP/*physiology
MH  - Cyclic AMP-Dependent Protein Kinases/metabolism
MH  - Enzyme Activation/drug effects
MH  - Lipopolysaccharides/*pharmacology
MH  - Lymphocyte Activation/*drug effects
MH  - Male
MH  - Mice
MH  - Spleen/cytology
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
PST - ppublish
SO  - Biochem Mol Biol Int. 1995 Mar;35(3):535-40.