PMID- 7773954
OWN - NLM
STAT- MEDLINE
DCOM- 19950713
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 81
IP  - 1
DP  - 1995 May
TI  - Clonal origin of Philadelphia chromosome negative cells with trisomy 8 appearing 
      during the course of alpha-interferon therapy for Ph positive chronic myelocytic 
      leukemia.
PG  - 20-3
AB  - The transient appearance of a Philadelphia chromosome (Ph) negative clone with 
      trisomy 8 was found in the bone marrow cells from a patient with Ph positive CML 
      during the course of alpha-interferon (IFN) therapy. To determine whether this 
      clone was derived from a Ph positive clone or from some other cell lineage, we 
      performed molecular cytogenetic studies on bone marrow cells from the patient by 
      fluorescence in situ hybridization (FISH). No fusion of BCR-ABL could be detected 
      in cells with trisomy 8, clearly indicating that the Ph negative trisomy 8 clone 
      was not derived from the Ph positive CML population.
FAU - Ariyama, T
AU  - Ariyama T
AD  - Department of Hygiene, Kyoto Prefectural University of Medicine, Japan.
FAU - Inazawa, J
AU  - Inazawa J
FAU - Uemura, Y
AU  - Uemura Y
FAU - Kakazu, N
AU  - Kakazu N
FAU - Maekawa, T
AU  - Maekawa T
FAU - Urase, F
AU  - Urase F
FAU - Irimajiri, K
AU  - Irimajiri K
FAU - Horiuchi, A
AU  - Horiuchi A
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Abe, T
AU  - Abe T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Interferon-alpha)
SB  - IM
MH  - Adult
MH  - Bone Marrow/*ultrastructure
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interferon-alpha/*therapeutic use
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/*therapy
MH  - *Philadelphia Chromosome
MH  - Trisomy/*genetics
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 0165460894001979 [pii]
AID - 10.1016/0165-4608(94)00197-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1995 May;81(1):20-3. doi: 10.1016/0165-4608(94)00197-9.