PMID- 7777035
OWN - NLM
STAT- MEDLINE
DCOM- 19950712
LR  - 20190909
IS  - 0301-486X (Print)
IS  - 0301-486X (Linking)
VI  - 128
IP  - 2
DP  - 1994 Nov
TI  - Developmental effects of fumonisin B1-containing Fusarium moniliforme culture 
      extract in CD1 mice.
PG  - 111-8
AB  - Pregnant Charles River CD1 mice were treated with a semipurified extract of 
      Fusarium moniliforme culture containing 0, 12.5, 25, 50 or 100 mg FB1/kg each day 
      orally (diluted in distilled water) between gestational days (GD) 7 and 15 to 
      evaluate the developmental toxicity of FB1. Following sacrifice of dams on GD 18, 
      litters were examined for gross abnormalities and divided equally for skeletal or 
      visceral examination by routine techniques. Significant maternal mortality was 
      observed at doses of 50 and 100 mg FB1/kg. Dose-dependent decreases in maternal 
      body weight gains, number of live offsprings per litter, and mean body weight of 
      the offspring were produced at FB1 doses of 25 mg/kg or higher. The percentage of 
      implants resorbed increased at all doses in a dose-dependant manner. A 
      dose-dependant increase, except at the lowest dose tested, in the incidence of 
      ossification deficits involving digits and sternum, short and wavy ribs, and 
      hydrocephalus of lateral and third ventricles was also evident. Cleft palate was 
      seen only at the highest FB1 dose. Maternal intoxication manifested as a 
      dose-dependant increase in the severity of ascites associated mainly with 
      increased histopathologic scores reflecting hepatocellular damage at day 18. 
      Concommittant increases in serum alanine amino transferase (ALT) on GD 12, 
      reflecting parenchymal liver cell damage, was also observed at all doses above 
      12.5 mg of FB1/kg. These results suggest that FB1-containing F. moniliforme 
      culture extract is developmentally toxic in mice, and that this toxicity may be 
      mediated by maternal hepatotoxicity.
FAU - Gross, S M
AU  - Gross SM
AD  - Departments of Veterinary Biomedical Sciences, College of Veterinary Medicine, 
      University of Missouri, Columbia, USA.
FAU - Reddy, R V
AU  - Reddy RV
FAU - Rottinghaus, G E
AU  - Rottinghaus GE
FAU - Johnson, G
AU  - Johnson G
FAU - Reddy, C S
AU  - Reddy CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mycopathologia
JT  - Mycopathologia
JID - 7505689
RN  - 0 (Fumonisins)
RN  - 0 (Mycotoxins)
RN  - 3ZZM97XZ32 (fumonisin B1)
SB  - IM
MH  - Abnormalities, Drug-Induced/*etiology
MH  - Animals
MH  - Chemical and Drug Induced Liver Injury/*etiology
MH  - Cleft Palate/chemically induced
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fetal Resorption/*chemically induced
MH  - *Fumonisins
MH  - Fusarium/*chemistry
MH  - Hydrocephalus/chemically induced
MH  - Litter Size/drug effects
MH  - Mice
MH  - Mycotoxins/isolation & purification/pharmacology/*toxicity
MH  - Pregnancy
MH  - Pregnancy Complications/*chemically induced
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 10.1007/BF01103018 [doi]
PST - ppublish
SO  - Mycopathologia. 1994 Nov;128(2):111-8. doi: 10.1007/BF01103018.