PMID- 7777509
OWN - NLM
STAT- MEDLINE
DCOM- 19950712
LR  - 20191210
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 92
IP  - 12
DP  - 1995 Jun 6
TI  - Age-related learning deficits in transgenic mice expressing the 751-amino acid 
      isoform of human beta-amyloid precursor protein.
PG  - 5341-5
AB  - The beta-amyloid precursor protein (beta-APP), from which the beta-A4 peptide is 
      derived, is considered to be central to the pathogenesis of Alzheimer disease 
      (AD). Transgenic mice expressing the 751-amino acid isoform of human beta-APP 
      (beta-APP751) have been shown to develop early AD-like histopathology with 
      diffuse deposits of beta-A4 and aberrant tau protein expression in the brain, 
      particularly in the hippocampus, cortex, and amygdala. We now report that 
      beta-APP751 transgenic mice exhibit age-dependent deficits in spatial learning in 
      a water-maze task and in spontaneous alternation in a Y maze. These deficits were 
      mild or absent in 6-month-old transgenic mice but were severe in 12-month-old 
      transgenic mice compared to age-matched wild-type control mice. No other 
      behavioral abnormalities were observed. These mice therefore model the 
      progressive learning and memory impairment that is a cardinal feature of AD. 
      These results provide evidence for a relationship between abnormal expression of 
      beta-APP and cognitive impairments.
FAU - Moran, P M
AU  - Moran PM
AD  - Marion Merrell Dow Research Institute, Strasbourg, France.
FAU - Higgins, L S
AU  - Higgins LS
FAU - Cordell, B
AU  - Cordell B
FAU - Moser, P C
AU  - Moser PC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Amyloid beta-Protein Precursor)
SB  - IM
MH  - Aging/*genetics/physiology
MH  - Amyloid beta-Protein Precursor/*genetics
MH  - Animals
MH  - Behavior, Animal
MH  - Female
MH  - Humans
MH  - Learning Disabilities/*genetics
MH  - Mice
MH  - Mice, Transgenic
PMC - PMC41690
EDAT- 1995/06/06 00:00
MHDA- 1995/06/06 00:01
PMCR- 1995/12/06
CRDT- 1995/06/06 00:00
PHST- 1995/06/06 00:00 [pubmed]
PHST- 1995/06/06 00:01 [medline]
PHST- 1995/06/06 00:00 [entrez]
PHST- 1995/12/06 00:00 [pmc-release]
AID - 10.1073/pnas.92.12.5341 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5341-5. doi: 10.1073/pnas.92.12.5341.