PMID- 7778448
OWN - NLM
STAT- MEDLINE
DCOM- 19950712
LR  - 20150901
IS  - 0001-6578 (Print)
IS  - 0001-6578 (Linking)
VI  - 36
IP  - 1
DP  - 1995 Jan-Feb
TI  - Experience of intravenous immunoglobulin and acyclovir in neonates at risk for 
      severe varicella infection--report of five cases.
PG  - 53-7
AB  - Five cases of at-risk neonates for severe varicella infection were reported. 
      Intravenous immunoglobulin (IVIG) was given soon after birth in different ways to 
      four of them (Case 1 received 400 mg/kg/day for the first three days of life; 
      Case 2 received a single dose of 200 mg/kg on day 2, and another dose of 160 
      mg/kg on day 7; Cases 3 and 4 received 400 mg/kg on day 2). All five patients 
      were given acyclovir therapy, 40 to 45 mg/kg/day for five to nine days. (Case 1 
      for prophylaxis, Cases 2, 3, 4, 5 for treatment). Case 2, 3, 4, 5 developed 
      vesicular rash, mild to moderate in degree, with rapid resolution without any 
      constitutional symptoms. Case 1, who received both IVIG and acyclovir for 
      prophylaxis, had no vesicle occurrence. IVIG, in combination with acyclovir, is a 
      safe and probably effective regimen for preventing severe varicella in at-risk 
      neonates. A multi-centered, collaborative study is mandatory to study the 
      efficacy of prophylactic acyclovir with IVIG in these neonates.
FAU - Lin, S J
AU  - Lin SJ
AD  - Department of Pediatrics, Chang Gung Memorial Hospital Taipei, Taiwan, Republic 
      of China.
FAU - Lin, T Y
AU  - Lin TY
FAU - Chiu, C H
AU  - Chiu CH
FAU - Huang, Y C
AU  - Huang YC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
JT  - Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er 
      ke yi xue hui
JID - 16210470R
RN  - 0 (Immunoglobulins, Intravenous)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - Acyclovir/*administration & dosage
MH  - Chickenpox/congenital/drug therapy/*prevention & control
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/*administration & dosage
MH  - Infant, Newborn
MH  - Male
MH  - Risk Factors
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1995 Jan-Feb;36(1):53-7.