PMID- 7778530
OWN - NLM
STAT- MEDLINE
DCOM- 19950713
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 75
IP  - 18
DP  - 1995 Jun 16
TI  - Comparison of the safety and efficacy of delapril with enalapril in patients with 
      congestive heart failure.
PG  - 25F-28F
AB  - To evaluate the safety and efficacy of delapril versus enalapril in patients with 
      congestive heart failure (CHF), New York Heart Association (NYHA) class II and 
      III, 198 patients were enrolled in a study in 13 centers involving a double-blind 
      parallel group design. After completing a 2-week run-in period on placebo, 
      patients were randomized to receive delapril 7.5 mg twice daily or enalapril 2.5 
      mg twice daily for 2 weeks. The dose was then doubled for the remaining 6 weeks. 
      In this phase, 1 patient in each group experienced orthostatic hypotension; the 
      dose was then reduced to the initial dose for study completion. A total of 195 
      patients received active treatment (96 delapril, 99 enalapril). After 8 weeks' 
      treatment, bicycle ergometry demonstrated a significant increase in exercise 
      duration (p < 0.01) and workload (p < 0.01). Echo Doppler investigations showed a 
      significant reduction (p < 0.01) in left ventricular end-systolic volume 
      associated with a significant increase (p < 0.01) in ejection fraction and 
      cardiac output. No clinically significant changes in blood pressure, heart rate, 
      electrocardiogram, or biochemical and hematologic tests were found. There were no 
      significant differences between treatment groups. Three patients in each group 
      experienced adverse reactions requiring withdrawal of 1 patient in each group. 
      Delapril 15 mg twice daily, like enalapril 5 mg twice daily, was effective in 
      improving signs and symptoms of CHF and was well tolerated.
FAU - Rengo, F
AU  - Rengo F
AD  - Clinica del Lavoro Foundation, Institute of Care, Italy.
FAU - Acanfora, D
AU  - Acanfora D
FAU - Furgi, G
AU  - Furgi G
FAU - Papa, A
AU  - Papa A
FAU - Nicolino, A
AU  - Nicolino A
FAU - Picone, C
AU  - Picone C
FAU - Vitale, D F
AU  - Vitale DF
FAU - Rengo, C
AU  - Rengo C
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Indans)
RN  - 69PN84IO1A (Enalapril)
RN  - W77UAL9THI (delapril)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Double-Blind Method
MH  - Echocardiography, Doppler
MH  - Enalapril/administration & dosage/adverse effects/*therapeutic use
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/*drug therapy/physiopathology
MH  - Humans
MH  - Indans/administration & dosage/adverse effects/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 1995/06/16 00:00
MHDA- 1995/06/16 00:01
CRDT- 1995/06/16 00:00
PHST- 1995/06/16 00:00 [pubmed]
PHST- 1995/06/16 00:01 [medline]
PHST- 1995/06/16 00:00 [entrez]
AID - S0002-9149(99)80511-6 [pii]
AID - 10.1016/s0002-9149(99)80511-6 [doi]
PST - ppublish
SO  - Am J Cardiol. 1995 Jun 16;75(18):25F-28F. doi: 10.1016/s0002-9149(99)80511-6.