PMID- 7778531
OWN - NLM
STAT- MEDLINE
DCOM- 19950713
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 75
IP  - 18
DP  - 1995 Jun 16
TI  - Comparison of the safety and efficacy of delapril with captopril in outpatients 
      with congestive heart failure.
PG  - 29F-36F
AB  - In this study delapril and captopril were compared in outpatients with congestive 
      heart failure (CHF), New York Heart Association (NYHA) classes III and IV, in a 
      double-blind study of efficacy and safety. Efficacy was evaluated by monitoring 
      changes in the NYHA classification, exercise work, hemodynamic parameters, 
      Kostuk's classification, and clinical signs and symptoms. Safety was monitored by 
      a variety of laboratory tests, including renal and hepatic function, urinalysis, 
      routine hematology testing, and the reporting of adverse events. Analysis of the 
      data obtained revealed that delapril and captopril exhibit equal efficacy over 
      the dosage ranges studied. There was a greater improvement of NYHA classification 
      in terms of CHF signs and symptoms and ergometric workload in the delapril group; 
      however, this did not reach statistical significance. The safety of the 2 drugs 
      was also comparable, with no significant differences in any of the parameters 
      measured at the start and end of the study. There was no statistically 
      significant difference in the reporting of adverse events between the 2 drugs, 
      although the sample size studied was small. There were no significant differences 
      between the 2 drugs in terms of their effects on arterial blood pressure and no 
      difference between prestudy and post-treatment arterial blood pressure 
      measurements.
FAU - Fuchs, W
AU  - Fuchs W
AD  - Takeda Pharma GmbH, Aachen, Germany.
LA  - eng
PT  - Clinical Trial
PT  - Clinical Trial, Phase III
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Indans)
RN  - 9G64RSX1XD (Captopril)
RN  - W77UAL9THI (delapril)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Ambulatory Care
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Captopril/administration & dosage/adverse effects/*therapeutic use
MH  - Double-Blind Method
MH  - Exercise Test/drug effects
MH  - Female
MH  - Heart Failure/*drug therapy/etiology/physiopathology
MH  - Humans
MH  - Indans/administration & dosage/adverse effects/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 1995/06/16 00:00
MHDA- 1995/06/16 00:01
CRDT- 1995/06/16 00:00
PHST- 1995/06/16 00:00 [pubmed]
PHST- 1995/06/16 00:01 [medline]
PHST- 1995/06/16 00:00 [entrez]
AID - S0002-9149(99)80512-8 [pii]
AID - 10.1016/s0002-9149(99)80512-8 [doi]
PST - ppublish
SO  - Am J Cardiol. 1995 Jun 16;75(18):29F-36F. doi: 10.1016/s0002-9149(99)80512-8.