PMID- 7778533
OWN - NLM
STAT- MEDLINE
DCOM- 19950713
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 75
IP  - 18
DP  - 1995 Jun 16
TI  - Congestive heart failure in elderly patients: controlled study of delapril versus 
      captopril.
PG  - 37F-43F
AB  - In this controlled trial, 30 elderly patients with congestive heart failure, New 
      York Heart Association (NYHA) classes II and III, were randomly assigned to 
      treatment with captopril 25 mg three times daily or delapril 15 mg twice daily. 
      At the end of an 8-week treatment period, clinical symptoms of heart failure were 
      significantly relieved by both drugs, with a consistent and statistically 
      significant improvement in patients' quality of life evaluated using a 
      symptoms/activity scale (p < 0.001). None of the patients was judged NYHA class 
      III at the end of the trial and 40% were assigned to class I (p < 0.01). There 
      was a relevant, but not statistically significant, increase in exercise duration 
      in both treatment groups (10% captopril group, 14% delapril group), but the 
      number of patients discontinuing the exercise test for dyspnea was 50% less in 
      the delapril group. Neither drug had evident effects on echocardiographic left 
      ventricular parameters. Two patients treated with captopril and 3 with delapril 
      complained of mild-to-moderate adverse reactions. The safety of both drugs was 
      confirmed by laboratory tests.
FAU - Acanfora, D
AU  - Acanfora D
AD  - Clinica del Lavoro Foundation, Institute of Care, Italy.
FAU - Lanzillo, T
AU  - Lanzillo T
FAU - Papa, A
AU  - Papa A
FAU - Longobardi, G
AU  - Longobardi G
FAU - Furgi, G
AU  - Furgi G
FAU - Rengo, C
AU  - Rengo C
FAU - Melillo, E
AU  - Melillo E
FAU - Rengo, F
AU  - Rengo F
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Indans)
RN  - 9G64RSX1XD (Captopril)
RN  - W77UAL9THI (delapril)
SB  - IM
MH  - Aged
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Captopril/administration & dosage/adverse effects/*therapeutic use
MH  - Exercise Test/drug effects
MH  - Female
MH  - Heart Failure/*drug therapy/physiopathology
MH  - Humans
MH  - Indans/administration & dosage/adverse effects/*therapeutic use
MH  - Male
MH  - Quality of Life
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Ventricular Function, Left/drug effects
EDAT- 1995/06/16 00:00
MHDA- 1995/06/16 00:01
CRDT- 1995/06/16 00:00
PHST- 1995/06/16 00:00 [pubmed]
PHST- 1995/06/16 00:01 [medline]
PHST- 1995/06/16 00:00 [entrez]
AID - S0002-9149(99)80513-X [pii]
AID - 10.1016/s0002-9149(99)80513-x [doi]
PST - ppublish
SO  - Am J Cardiol. 1995 Jun 16;75(18):37F-43F. doi: 10.1016/s0002-9149(99)80513-x.