PMID- 7779440
OWN - NLM
STAT- MEDLINE
DCOM- 19950718
LR  - 20170214
IS  - 0960-3271 (Print)
IS  - 0960-3271 (Linking)
VI  - 14
IP  - 2
DP  - 1995 Feb
TI  - Decorporation of thorium-228 from the rat by 3,4,3-LIHOPO and DTPA after 
      simulated wound contamination.
PG  - 165-9
AB  - 1. With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been 
      examined for its ability to remove 228Th nitrate from the rat after subcutaneous 
      (sc) and intramuscular (im) injection to simulate wound contamination. The 
      commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed 
      at 7 d. 2. In all cases 3,4,3-LIHOPO was appreciably more effective than DTPA 
      although the efficacy of treatment and the relative effectiveness of the ligands 
      decreased rapidly with their delay in administration. 3. Optimum removal with 
      both ligands occurred when initial local administration at 30 min after exposure 
      was followed by repeated intraperitoneal injection at 6 h, 1, 2 and 3 d. Under 
      these conditions the body content of 228Th was reduced to 20% of controls after 
      sc injection and 15% after im injection. The corresponding values using repeated 
      DTPA administration were 80% and 54%. 4. It is concluded that 3,4,3-LIHOPO 
      represents, potentially, a considerable advance on DTPA, the current agent of 
      choice for the treatment of wounds contaminated by 228Th.
FAU - Stradling, G N
AU  - Stradling GN
AD  - National Radiological Protection Board, Didcot, Oxon, UK.
FAU - Gray, S A
AU  - Gray SA
FAU - Pearce, M J
AU  - Pearce MJ
FAU - Wilson, I
AU  - Wilson I
FAU - Moody, J C
AU  - Moody JC
FAU - Burgada, R
AU  - Burgada R
FAU - Durbin, P W
AU  - Durbin PW
FAU - Raymond, K N
AU  - Raymond KN
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Aza Compounds)
RN  - 0 (Ligands)
RN  - 0 (Pyridones)
RN  - 0 (Thorium Compounds)
RN  - 144674-91-9 
      (N,N',N'',N'''-tetra(1,2-dihydro-1-hydroxy-2-oxopyridine-6-carbonyl)-1,5,10,14-tetraazatetradecane)
RN  - 7A314HQM0I (Pentetic Acid)
RN  - IF944P467K (thorium nitrate)
SB  - IM
MH  - Animals
MH  - Aza Compounds/administration & dosage/*pharmacology
MH  - Disease Models, Animal
MH  - Female
MH  - Injections, Intramuscular
MH  - Injections, Intraperitoneal
MH  - Injections, Subcutaneous
MH  - Kinetics
MH  - Ligands
MH  - Pentetic Acid/administration & dosage/*pharmacology
MH  - Pyridones/administration & dosage/*pharmacology
MH  - Rats
MH  - Thorium Compounds/administration & dosage/*metabolism/toxicity
MH  - Wound Healing/drug effects
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 10.1177/096032719501400202 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 1995 Feb;14(2):165-9. doi: 10.1177/096032719501400202.