PMID- 7781336
OWN - NLM
STAT- MEDLINE
DCOM- 19950719
LR  - 20190514
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 107
IP  - 6
DP  - 1995 Jun
TI  - Neurohormonal activation and exercise function in patients with severe heart 
      failure and patients with left ventricular assist system. A comparative study.
PG  - 1499-503
AB  - OBJECTIVES: The aim of this study was to evaluate the effects of implantation of 
      a left ventricular assist system (LVAS) on the neurohormonal status, exercise 
      capacity and symptomatic state in patients with severe congestive heart failure 
      (CHF). BACKGROUND: Severe CHF is characterized by decreased exercise tolerance 
      and activation of several neurohormonal systems. METHODS: Parameters of 
      neurohormonal activation and exercise capacity in patients with LVAS (n = 7) were 
      compared with those in groups of New York Heart Association (NYHA) class 3 (n = 
      121) and class 4 (n = 81) patients. Plasma levels of norepinephrine (NE), plasma 
      renin activity (PRA), and atrial natriuretic peptide (ANP) and maximal and 
      submaximal exercise capacities were measured monthly in LVAS patients and 
      compared with results in CHF patients. RESULTS: Plasma NE and PRA levels were 
      significantly lower in LVAS patients than in NYHA class 4 patients, and plasma 
      ANP levels in LVAS patients were significantly lower than those in NYHA class 3 
      and 4 patients. The distance walked during submaximal exercise testing and peak 
      oxygen consumption during maximal exercise testing were similar for the LVAS and 
      NYHA class 3 patients. The class 4 patients were unable to exercise. CONCLUSIONS: 
      We conclude that the LVAS lessens the neurohormonal activation and exercise 
      intolerance characteristic of the CHF state and that the exercise capacity early 
      after LVAS (< 4 months) is similar to that observed in NYHA class 3 patients.
FAU - Estrada-Quintero, T
AU  - Estrada-Quintero T
AD  - Department of Medicine, University of Pittsburgh Medical Center, Presbyterian 
      University Hospital.
FAU - Uretsky, B F
AU  - Uretsky BF
FAU - Murali, S
AU  - Murali S
FAU - Griffith, B P
AU  - Griffith BP
FAU - Kormos, R L
AU  - Kormos RL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (Neurotransmitter Agents)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - EC 3.4.23.15 (Renin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Atrial Natriuretic Factor/blood
MH  - Cardiac Output
MH  - *Exercise Tolerance
MH  - Female
MH  - Heart Failure/metabolism/*physiopathology/surgery
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurotransmitter Agents/*blood
MH  - Norepinephrine/blood
MH  - Oxygen Consumption
MH  - Renin/blood
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - S0012-3692(16)35764-6 [pii]
AID - 10.1378/chest.107.6.1499 [doi]
PST - ppublish
SO  - Chest. 1995 Jun;107(6):1499-503. doi: 10.1378/chest.107.6.1499.