PMID- 7782269
OWN - NLM
STAT- MEDLINE
DCOM- 19950720
LR  - 20191101
IS  - 0910-8327 (Print)
IS  - 0910-8327 (Linking)
VI  - 10
IP  - 2
DP  - 1995
TI  - Regional diastolic function in effort angina pectoris: assessment with biplane 
      left ventriculography.
PG  - 87-95
AB  - To investigate left ventricular (LV) regional diastolic function in effort angina 
      pectoris (AP), we performed left ventriculography in 14 patients with AP and 
      isolated left anterior descending artery disease and in 9 normal subjects (N). LV 
      volume (V), regional area (S) [anterior, apex, and inferior], and the first 
      derivative of V and S (dV/dt, dS/dt) were derived from analysis of the left 
      ventriculogram. Normalized peak filling rate (nPFR) and peak atrial filling rate 
      (nPAFR) were derived from dV/dt. The ratio of filling volume to stroke volume 
      during rapid filling and atrial contraction were defined as rapid filling 
      fraction (RFF) and atrial filling fraction (AFF). Similarly, peak area changing 
      rate (PACR), peak area changing rate during atrial contraction (PACRac), rapid 
      area changing fraction (RACF), and atrial area changing fraction (AACF) were 
      derived from S and dS/dt. We also calculated the time constant of LV relaxation 
      (T), and LV global and regional compliance during atrial contraction [(dV/VdP)ac, 
      (dS/SdP)ac]. The LV global diastolic function (T increases, nPFR decreases) was 
      impaired in the angina patients. LV regional diastolic function (nPACR decreases, 
      RACF decreases) was also impaired in the affected region of the AP group. While 
      their rapid filling was impaired, nPACRac was maintained and AACF was increased 
      in the affected region. Furthermore, nPACR and RACF each showed a significant 
      inverse correlation with AACF in the anterior region [r = -0.57 (P < 0.01), r = 
      -0.92 (P < 0.001)]. In the affected region of the patients with AP, (dS/SdP)ac 
      was increased, but not significantly. Thus, LV global and regional diastolic 
      functions were simultaneously impaired in patients with isolated left anterior 
      descending artery disease.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Tamura, A
AU  - Tamura A
AD  - Second Department of Internal Medicine, Yamaguchi University School of Medicine, 
      Japan.
FAU - Katayama, K
AU  - Katayama K
FAU - Yamamoto, T
AU  - Yamamoto T
FAU - Ikeda, Y
AU  - Ikeda Y
FAU - Seki, K
AU  - Seki K
FAU - Hiro, T
AU  - Hiro T
FAU - Yano, M
AU  - Yano M
FAU - Miura, T
AU  - Miura T
FAU - Kohno, M
AU  - Kohno M
FAU - Fujii, T
AU  - Fujii T
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Angina Pectoris/*physiopathology
MH  - Compliance
MH  - Diastole
MH  - Female
MH  - Heart Atria/physiopathology
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Contraction
MH  - Radiography
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Ventricular Function, Left
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/BF01744499 [doi]
PST - ppublish
SO  - Heart Vessels. 1995;10(2):87-95. doi: 10.1007/BF01744499.