PMID- 7783878
OWN - NLM
STAT- MEDLINE
DCOM- 19950718
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 45
IP  - 6
DP  - 1995 Jun
TI  - Increased iron-related MRI contrast in the substantia nigra in Parkinson's 
      disease.
PG  - 1138-43
AB  - Elevated iron levels in the substantia nigra (SN) of the brain in Parkinson's 
      disease (PD) may mediate lipid peroxidative reactions, promoting SN neuronal 
      death. To assess SN iron accumulation in living PD patients and its relation to 
      motor performance, we measured, in 13 nondemented PD patients and 10 normal 
      control subjects, simple reaction time (SRT) and simple movement time (SMT), 
      followed by head MRI in a 3-tesla system. We measured T2 and T2* in the right and 
      left SN of all subjects and calculated R2', the relaxation rate due to local 
      magnetic field in-homogeneities, from these values. Asymmetries of 1/T2 (R2), 
      1/T2* (R2*), or R2' versus asymmetries of SRT and SMT were assessed in eight PD 
      subjects who had not taken anti-PD medication(s) for 12 hours. The average of 
      right and left SN values for R2 was lower, and R2* and R2' were higher, in PD 
      patients than in controls (R2, p = 0.046; R2*, p = 0.001; R2', p < 0.001). R2' 
      best predicted group differences. The asymmetry of SRT performance was highly 
      correlated with asymmetries of SN R2* (0.91; p = 0.001) and R2' (0.72; p = 0.03). 
      These results strongly suggest that the increases in iron levels seen postmortem 
      in the SN in PD are reflected in increased iron-related MRI contrast at 3 tesla 
      in living PD patients. Correlations with motor performance in PD suggest that the 
      clinical severity of PD may be related to SN iron accumulation.
FAU - Gorell, J M
AU  - Gorell JM
AD  - Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, 
      MI 48202, USA.
FAU - Ordidge, R J
AU  - Ordidge RJ
FAU - Brown, G G
AU  - Brown GG
FAU - Deniau, J C
AU  - Deniau JC
FAU - Buderer, N M
AU  - Buderer NM
FAU - Helpern, J A
AU  - Helpern JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - E1UOL152H7 (Iron)
SB  - IM
EIN - Neurology 1995 Jul;45(7):1420
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Iron/*metabolism
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*metabolism/pathology
MH  - Substantia Nigra/*metabolism/pathology
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 10.1212/wnl.45.6.1138 [doi]
PST - ppublish
SO  - Neurology. 1995 Jun;45(6):1138-43. doi: 10.1212/wnl.45.6.1138.