PMID- 7786773
OWN - NLM
STAT- MEDLINE
DCOM- 19950727
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 90
IP  - 1
DP  - 1995 May
TI  - Der(16)t(1;16)(q11;q11) in myelodysplastic syndromes: a new non-random 
      abnormality characterized by cytogenic and fluorescence in situ hybridization 
      studies.
PG  - 119-24
AB  - The der(16)t(1;16)(q11;q11) is a frequent recurrent rearrangement in solid 
      tumours such as breast carcinomas and Ewings sarcomas. Recently, this abnormality 
      was described also in multiple myeloma. We identified a der(16)t(1;16)(q11;q11) 
      in three patients with myelodysplastic syndrome, either during preleukaemic phase 
      (n = 2) or at the time of blastic transformation (n = 1). Breakpoints were 
      ascertained by fluorescence in situ hybridization (FISH) using specific 
      centromeric alpha-satellite probes and whole chromosome painting for chromosome 1 
      and chromosome 16. These observations, combined with isolated cases of the 
      literature, suggest that der(16)t(1;16)(q11; q11) is a nonrandom abnormality 
      associated with myelodysplastic syndromes.
FAU - Mugneret, F
AU  - Mugneret F
AD  - Laboratory of Cytogenetics, Faculty of Medicine, Dijon, France.
FAU - Dastugue, N
AU  - Dastugue N
FAU - Favre, B
AU  - Favre B
FAU - Sidaner, I
AU  - Sidaner I
FAU - Salles, B
AU  - Salles B
FAU - Huguet-Rigal, F
AU  - Huguet-Rigal F
FAU - Solary, E
AU  - Solary E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (DNA Probes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cell Transformation, Neoplastic/genetics
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 16
MH  - DNA Probes
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
MH  - Preleukemia/genetics
MH  - *Translocation, Genetic
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1111/j.1365-2141.1995.tb03389.x [doi]
PST - ppublish
SO  - Br J Haematol. 1995 May;90(1):119-24. doi: 10.1111/j.1365-2141.1995.tb03389.x.