PMID- 7786916
OWN - NLM
STAT- MEDLINE
DCOM- 19950727
LR  - 20161123
IS  - 0368-3249 (Print)
IS  - 0368-3249 (Linking)
VI  - 38
IP  - 4
DP  - 1994 Dec
TI  - Locating neuroblastoma in the opsoclonus-myoclonus syndrome.
PG  - 545-55
AB  - We examined the role of various medical imaging modalities, particularly 
      metaiodobenzylguanidine (MIBG) scintigraphy in the investigation of patients 
      presenting with the opsoclonus-myoclonus syndrome (OMS) who may harbor 
      neuroblastomas. A retrospective analysis was therefore performed of all patients 
      presenting with OMS in a 5 1/2 year period. Between December, 1988 and May, 1994, 
      all 13 patients (mean age 15.2 months, range 3 days-30 months) presenting with 
      OMS were extensively studied. A wide range of medical imaging modalities 
      including CT, MRI and [131I] or [123I]-metaiodobenzylguanidine (MIBG) 
      scintigraphy (total of 21 scans) were examined as a means of detecting a 
      structural brain lesion or locating a neuroblastoma, a tumor generally found in 
      less than half of patients with OMS. As anticipated a minority of patients (4) 
      were eventually found to harbor neuroblastomas. In these four cases, two tumors 
      were revealed on preoperative MIBG scintigraphy, one gave a false negative study 
      and one tumor was not studied preoperatively. Each patient was also subjected to 
      extensive radiological investigations in addition to MIBG scintigraphy, many of 
      which were repetitive, redundant or had low clinical yield. The relative merits 
      of the various procedures are compared, and an algorithm incorporating MIBG 
      scintigraphy and limited central nervous system and abdominal anatomical 
      modalities for the investigation of opsoclonus-myoclonus is suggested.
FAU - Shapiro, B
AU  - Shapiro B
AD  - Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 
      48109-0028, USA.
FAU - Shulkin, B L
AU  - Shulkin BL
FAU - Hutchinson, R J
AU  - Hutchinson RJ
FAU - Bass, J C
AU  - Bass JC
FAU - Gross, M D
AU  - Gross MD
FAU - Sisson, J C
AU  - Sisson JC
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Nucl Biol Med (1991)
JT  - Journal of nuclear biology and medicine (Turin, Italy : 1991)
JID - 9110209
RN  - 0 (Contrast Media)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Iodobenzenes)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
SB  - IM
MH  - 3-Iodobenzylguanidine
MH  - Child, Preschool
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Iodine Radioisotopes
MH  - Iodobenzenes
MH  - Male
MH  - Myoclonus/*etiology
MH  - Neuroblastoma/complications/*diagnostic imaging
MH  - Ocular Motility Disorders/*etiology
MH  - Radionuclide Imaging
MH  - Retrospective Studies
MH  - Syndrome
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
PST - ppublish
SO  - J Nucl Biol Med (1991). 1994 Dec;38(4):545-55.