PMID- 7787757
OWN - NLM
STAT- MEDLINE
DCOM- 19950724
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 16
IP  - 5-6
DP  - 1995 Feb
TI  - Acute myeloblastic leukemia associated with an intermediate state between the 
      healthy carrier state and adult T-cell leukemia.
PG  - 505-9
AB  - This report describes an intermediate state between the human T-cell lymphotropic 
      virus type I (HTLV-I) healthy carrier and adult T-cell Leukemia (ATL) who 
      developed acute myeloblastic leukemia (AML, FAB subtype M2). The polyclonal 
      integration of HTLV-I proviral DNA was demonstrated in the peripheral blood 
      lymphoid cells, whereas AML cells had no HTLV-I proviral DNA. The patient 
      achieved remission after combination chemotherapy but cells with lobulated nuclei 
      persist at a low level and the polyclonal integration of HTLV-I proviral DNA is 
      still demonstrated. We suggest that the patients with the integration of HTLV-I 
      proviral DNA might develop secondary neoplasms more frequently than healthy 
      carriers and this case stresses the need to exercise caution with these patients. 
      The relationship between HTLV-I and AML is briefly discussed.
FAU - Kawachi, Y
AU  - Kawachi Y
AD  - Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan.
FAU - Watanabe, A
AU  - Watanabe A
FAU - Sakamoto, Y
AU  - Sakamoto Y
FAU - Abe, T
AU  - Abe T
FAU - Uchida, T
AU  - Uchida T
FAU - Sacho, M
AU  - Sacho M
FAU - Mori, M
AU  - Mori M
FAU - Setsu, K
AU  - Setsu K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (DNA, Viral)
SB  - IM
GS  - pX
MH  - Adult
MH  - *Carrier State/virology
MH  - DNA, Viral/isolation & purification
MH  - Disease Susceptibility
MH  - Human T-lymphotropic virus 1/isolation & purification
MH  - Humans
MH  - Immunocompromised Host
MH  - *Leukemia, Myeloid, Acute
MH  - *Leukemia-Lymphoma, Adult T-Cell/virology
MH  - Male
MH  - *Neoplasms, Multiple Primary
MH  - Neoplastic Stem Cells/pathology/virology
MH  - Proviruses/isolation & purification
RF  - 14
EDAT- 1995/02/01 00:00
MHDA- 1995/02/01 00:01
CRDT- 1995/02/01 00:00
PHST- 1995/02/01 00:00 [pubmed]
PHST- 1995/02/01 00:01 [medline]
PHST- 1995/02/01 00:00 [entrez]
AID - 10.3109/10428199509054440 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 1995 Feb;16(5-6):505-9. doi: 10.3109/10428199509054440.