PMID- 7789379
OWN - NLM
STAT- MEDLINE
DCOM- 19950727
LR  - 20190512
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 16
IP  - 3
DP  - 1995 Mar
TI  - Heart rate variability and functional severity of congestive heart failure 
      secondary to coronary artery disease.
PG  - 360-7
AB  - To investigate the behaviour of heart rate variability (HRV) with the advancing 
      severity of heart failure (CHF) we studied 20 normal subjects and 80 coronary 
      artery disease (CAD) patients in sinus rhythm. CAD patients were selected 
      consecutively in order to form four equal groups of 20 subjects with different 
      degrees of CHF according to the New York Heart Association (NYHA) functional 
      classification. In each subject a 24 h ECG Holter tape was recorded and 
      subsequently analysed to obtain measures of heart rate and HRV. We used several 
      measures of HR and both spectral and non-spectral measures of HRV. Among these we 
      employed the width of the R-R interval distribution over 24 h at three different 
      heights (TV, 10%Var, 50%Var). The CAD group showed significantly lower HRV counts 
      and smaller spectral components than controls. However, these differences were 
      due to the presence of CHF rather than to CAD. Indeed, a progressive and 
      significant increase in heart rate and a contemporary decrease in HRV was 
      observed with the advancing severity of CHF. Class IV patients had the smallest 
      HR variation; the spectral composition in this group was barely detectable. The 
      decrease in time domain measures of HRV followed the increase in NYHA Class in a 
      progressive and regular pattern, while the low frequency and high frequency 
      spectral power showed the largest reduction from NYHA Class I to NYHA Class II 
      patients. No significant change was demonstrated in NYHA Class I patients as 
      compared to Controls.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Casolo, G C
AU  - Casolo GC
AD  - Cardiology Unit, Ospedale San Giovanni di Dio, Florence, Italy.
FAU - Stroder, P
AU  - Stroder P
FAU - Sulla, A
AU  - Sulla A
FAU - Chelucci, A
AU  - Chelucci A
FAU - Freni, A
AU  - Freni A
FAU - Zerauschek, M
AU  - Zerauschek M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Adult
MH  - Aged
MH  - Coronary Disease/classification/diagnosis/*physiopathology
MH  - *Electrocardiography
MH  - Female
MH  - Fourier Analysis
MH  - Heart Failure/classification/diagnosis/*physiopathology
MH  - Heart Rate/*physiology
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Signal Processing, Computer-Assisted
MH  - Ventricular Function, Left/physiology
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.eurheartj.a060919 [doi]
PST - ppublish
SO  - Eur Heart J. 1995 Mar;16(3):360-7. doi: 10.1093/oxfordjournals.eurheartj.a060919.