PMID- 7794268
OWN - NLM
STAT- MEDLINE
DCOM- 19950724
LR  - 20131121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 211
IP  - 2
DP  - 1995 Jun 15
TI  - Peritoneal macrophages from stroke-prone spontaneously hypertensive rats 
      accumulate more cholesteryl ester than do macrophages from Wistar-Kyoto rats.
PG  - 547-53
AB  - The intracellular cholesterol metabolism of peritoneal macrophages from 
      stroke-prone spontaneously hypertensive rats (SHRSP) was compared to that of 
      normotensive Wistar-Kyoto rats (WKY) in order to examine the role of macrophages 
      in the development of arterial fat deposits in the SHRSP. Scavenger receptor 
      activity and intracellular acyl CoA:cholesterol acyltransferase (ACAT) activity 
      were significantly higher in macrophages from SHRSP compared to findings in WKY, 
      in the presence of modified low-density lipoprotein (LDL), acetylated-LDL 
      (Ac-LDL). Moreover, macrophages from the SHRSP accumulated more cholesteryl ester 
      than seen in WKY in response to Ac-LDL. ACAT activity and cholesteryl ester 
      accumulation were inhibited by specific ACAT inhibitor, HL-004, to a similar 
      extent, in macrophages from WKY and SHRSP. These findings suggest the 
      susceptibility of SHRSP to arterial fat deposits.
FAU - Murakami, S
AU  - Murakami S
AD  - Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.
FAU - Nara, Y
AU  - Nara Y
FAU - Yamori, Y
AU  - Yamori Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Cholesterol Esters)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Lipoprotein)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (Scarb1 protein, mouse)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 2.3.1.26 (Sterol O-Acyltransferase)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Cerebrovascular Disorders
MH  - Cholesterol/metabolism
MH  - Cholesterol Esters/*metabolism
MH  - Lipoproteins, LDL/pharmacology
MH  - Macrophages, Peritoneal/drug effects/*metabolism
MH  - Male
MH  - *Membrane Proteins
MH  - Rats
MH  - Rats, Inbred SHR/*metabolism
MH  - Rats, Inbred WKY/*metabolism
MH  - Receptors, Immunologic/*metabolism
MH  - *Receptors, Lipoprotein
MH  - Receptors, Scavenger
MH  - Scavenger Receptors, Class B
MH  - Species Specificity
MH  - Sterol O-Acyltransferase/metabolism
EDAT- 1995/06/15 00:00
MHDA- 1995/06/15 00:01
CRDT- 1995/06/15 00:00
PHST- 1995/06/15 00:00 [pubmed]
PHST- 1995/06/15 00:01 [medline]
PHST- 1995/06/15 00:00 [entrez]
AID - S0006-291X(85)71848-7 [pii]
AID - 10.1006/bbrc.1995.1848 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1995 Jun 15;211(2):547-53. doi: 
      10.1006/bbrc.1995.1848.