PMID- 7795309
OWN - NLM
STAT- MEDLINE
DCOM- 19950803
LR  - 20170214
IS  - 0267-6591 (Print)
IS  - 0267-6591 (Linking)
VI  - 10
IP  - 1
DP  - 1995
TI  - The role of N-acetylcystein administration on the oxidative response of 
      neutrophils during cardiopulmonary bypass.
PG  - 21-6
AB  - The role of N-acetylcystein (NAC) administration on the oxidative response of 
      neutrophils during cardiopulmonary bypass (CPB) was evaluated in a double-blind 
      study. Twenty-four adult patients undergoing coronary artery bypass were included 
      in the study. Twelve patients received NAC as a bolus of 100 mg/kg followed by a 
      continuous infusion of 20 mg/kg/h in the bypass circuit from the beginning to the 
      end of bypass. A further 12 patients received placebo. Citrated blood samples for 
      measurement of oxidative burst response of neutrophils were obtained at different 
      time points during bypass. The oxidative burst response of neutrophils in the 
      patients receiving NAC was significantly low at all times during bypass. Based on 
      these findings NAC appears to act as an oxygen free radical scavenger during 
      open-heart surgery.
FAU - Andersen, L W
AU  - Andersen LW
AD  - Department of Cardiac Anaesthesia, National University Hospital, Rigshospitalet, 
      Copenhagen, Denmark.
FAU - Thiis, J
AU  - Thiis J
FAU - Kharazmi, A
AU  - Kharazmi A
FAU - Rygg, I
AU  - Rygg I
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Perfusion
JT  - Perfusion
JID - 8700166
RN  - 11062-77-4 (Superoxides)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*pharmacology
MH  - *Cardiopulmonary Bypass
MH  - Double-Blind Method
MH  - Humans
MH  - Luminescent Measurements
MH  - Middle Aged
MH  - Neutrophils/*drug effects/metabolism
MH  - Oxidation-Reduction/drug effects
MH  - Superoxides/blood
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1177/026765919501000105 [doi]
PST - ppublish
SO  - Perfusion. 1995;10(1):21-6. doi: 10.1177/026765919501000105.